{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:04:37Z","timestamp":1762506277602},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). Novel biomarkers are necessary to enhance the diagnostic accuracy, prognostic stratification, monitoring of treatment response, and detection of early renal flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study was conducted on 90 participants. They were divided into three groups, group I (controls) encompassed 30 ages and sex\u2010matched healthy personnel. Group II included 30 non\u2010nephritic SLE patients and finally group III included 30 SLE nephritic patients. Urinary monocyte chemoattractant protein\u20101 (UMCP\u20101) and hepcidin were evaluated by ELISA technique, compared and correlated in different groups, with each other and with other routine variables and with renal biopsy done to study group (III).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both UMCP\u20101 and hepcidin in group III showed significant increase compared to other two groups (controls and group II) (468 \u00b1 128, 111 \u00b1 12, 252 \u00b1 56 pg\/ml, respectively, for UMCP\u20101 and 40 \u00b1 12, 11 \u00b1 2, 20 \u00b1 5 ng\/ml, respectively, for hepcidin, <jats:italic>P<\/jats:italic> &lt; 0.01). Also both UMCP\u20101 and hepcidin in group III showed significant increase in diffuse proliferative subgroup compared to focal proliferative and mesangioproliferative subgroups (580 \u00b1 43, 502 \u00b1 46, and 352.6 \u00b1 100 pg\/ml, respectively, for UMCP\u20101 and 47.8 \u00b1 9.5, 41.4 \u00b1 6, and 32.9 \u00b1 10.8 ng\/ml, respectively, for urinary hepcidin, <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UMCP\u20101 and hepcidin could be associated with the susceptibility of lupus nephritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21685","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T23:16:54Z","timestamp":1393543014000},"page":"306-309","source":"Crossref","is-referenced-by-count":15,"title":["A Study of Hepcidin and Monocyte Chemoattractant Protein\u20101 in Egyptian Females With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"28","author":[{"given":"Moataz Fatthy","family":"Mohammed","sequence":"first","affiliation":[{"name":"Internal Medicine Department Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawlat","family":"Belal","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seham","family":"Bakry","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Marie","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Rashed","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham Emad","family":"Eldin","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah Abd","family":"El\u2010Hamid","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2057oa"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728210903535878"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"187","article-title":"Biomarker discovery inhuman SLE nephritis","volume":"65","author":"Rovin BH","year":"2007","journal-title":"Bull NYU Hosp Jt 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