{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T12:27:43Z","timestamp":1748262463059},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T00:00:00Z","timestamp":1395446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Background<\/jats:title>After hematopoietic stem cell transplantation (HSCT<\/jats:styled-content>), early detection of engraftment would be of critical value for clinicians. The aim of this study was to identify faster parameters for engraftment.<\/jats:p><\/jats:sec>Methods<\/jats:title>We evaluated blood cell parameters including complete blood count (CBC), differential counts, and various reticulocyte parameters in 115 patients who received HSCT<\/jats:styled-content> (allogeneic, n<\/jats:italic> = 93; autologous, n<\/jats:italic> = 22) in the purpose of identifying possible improved laboratory guidelines for engraftment prediction.<\/jats:p><\/jats:sec>Results and Conclusion<\/jats:title>Days to white blood cell (WBC<\/jats:styled-content>) count over 100 cells\/\u03bcl with more than two\u2010fold increase from nadir after transplantation (proposed new WBC<\/jats:styled-content> guideline) preceded absolute neutrophil count (ANC<\/jats:styled-content>) >500 cells\/\u03bcl by 1.7 days. Among erythroid parameters, the earliest marker for erythroid engraftment was high light scattering reticulocytes (HLR<\/jats:styled-content>) >0.1 (proposed new red blood cell guideline), which preceded reticulocyte counts (RET<\/jats:styled-content>) >1% and immature reticulocyte fraction >0.5 by 3.9 and 1.6 days, respectively. Among the clinical parameters compared, those with statistically significant influence on myeloid engraftment were donor type (P<\/jats:italic> = 0.009) and conditioning intensity (P<\/jats:italic> = 0.009). As for erythroid recovery, ABO<\/jats:styled-content> incompatibility was the only significant factor. In conclusion, the new guidelines may ensure engraftment several days earlier than the conventional parameters, which may help clinicians for decision\u2010making on rescue therapy earlier.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21712","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T18:53:25Z","timestamp":1395514405000},"page":"469-477","source":"Crossref","is-referenced-by-count":3,"title":["New Proposed Guidelines for Early Identification of Successful Myeloid and Erythroid Engraftment in Hematopoietic Stem Cell Transplantation"],"prefix":"10.1002","volume":"28","author":[{"given":"Seung\u2010Ah","family":"Yahng","sequence":"first","affiliation":[{"name":"Department of Hematology College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myungshin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Jee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon\u2010Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine, The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungja","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine College of Medicine, The Catholic University of Korea Seoul 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