{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T13:37:46Z","timestamp":1703079466880},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T00:00:00Z","timestamp":1395446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Asian, Siberian, and American ginseng are known to interfere with serum digoxin measurements using fluorescence polarization technology, Digoxin II and Digoxin III assays (Abbott Laboratories, Green oaks, IL) as well as other digoxin assays. Abbott Laboratories more recently launched two new digoxin assays: iDigoxin, a chemiluminescent microparticle immunoassay for application on the ARCHITECT i1000SR and i2000SR immunoassay analyzers, and cDigoxin, a particle\u2010enhanced turbidimetric inhibition immunoassay for application on the ARCHITECT c4000, c8000, and c1600 clinical chemistry analyzers; and we studied potential interferences of ginsengs with these two assays in vitro. When aliquots of drug\u2010free serum pool treated with activated charcoal were supplemented with extracts of various ginsengs, no significant apparent digoxin values were observed. In addition, when aliquots of the digoxin pool prepared from patients taking digoxin were further supplemented with these ginseng extracts and the digoxin values were re\u2010measured, we observed no statistically significant difference in observed digoxin values compared to the original digoxin value of the pool. These results further establish that relatively new digoxin assays for application on the ARCHITECT analyzers that employ specific monoclonal antibodies against digoxin are free from interferences from Asian, Siberian, and American ginseng.<\/jats:p>","DOI":"10.1002\/jcla.21714","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T18:53:27Z","timestamp":1395514407000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Digoxin Immunoassays on the ARCHITECT i2000SR and ARCHITECT c8000 Analyzers Are Free From Interferences of Asian, Siberian, and American Ginseng"],"prefix":"10.1002","volume":"29","author":[{"given":"Bennett W.","family":"Baugher","sequence":"first","affiliation":[{"name":"Abbott Laboratories  Green Oaks Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Berman","sequence":"additional","affiliation":[{"name":"Abbott Laboratories  Green Oaks Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Dierksen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Texas\u2010Houston Medical School  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Abbott Laboratories  Green Oaks Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitava","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Texas\u2010Houston Medical School  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2384"},{"key":"e_1_2_5_3_1","first-page":"1435","article-title":"Effect of American ginseng (Panax quinquefolius) on glycemic control in type 2 diabetes","volume":"36","author":"Mucalo I","year":"2012","journal-title":"Coll Antropol"},{"key":"e_1_2_5_4_1","first-page":"450","article-title":"Herbal use in ED patients","volume":"8","author":"Gulla J","year":"2001","journal-title":"Acad Emerg Med"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/34BJECP7UK6FH13V"},{"key":"e_1_2_5_6_1","first-page":"293","article-title":"Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng","volume":"155","author":"McRae S","year":"1996","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/34BJECP7UK6FH13V"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/UTFTK2LH1RMHCBD7"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20252"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181fd4c30"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00075-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.091"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.21714","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.21714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:33:05Z","timestamp":1696401185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.21714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,22]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/jcla.21714"],"URL":"https:\/\/doi.org\/10.1002\/jcla.21714","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,22]]}}}