{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:54:15Z","timestamp":1792684455505,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T00:00:00Z","timestamp":1400630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In recent years, white blood cells (WBCs) and their subtypes have been studied in relation to inflammation. The aim of our study was to assess the relationship between neutrophil\u2013lymphocyte ratio (NLR) and ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We enrolled a total of 177 patients, 96 AS and 81 healthy controls. Complete blood count, WBC, neutrophil and lymphocyte levels were measured, and the NLR was calculated. In the assessment of AS, we used the erythrocyte sedimentation rate, C\u2010reactive protein (CRP), the Bath Ankylosing Spondylitis Disease Activity Index, and the Bath Ankylosing Spondylitis Functional Index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the present study, 96 AS and 81 healthy individuals were enrolled. The mean age was 43.8 \u00b1 12.9 and 46.5 \u00b1 11.2 years, respectively. Mean disease duration of AS patients was 6.9 \u00b1 5.6 years (median = 5, min\u2013max = 1\u201325). The patients with AS had a higher NLR than the control individuals (mean NLR, 2.24 \u00b1 1.23 and 1.73 \u00b1 0.70, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001). A statistically significant positive correlation was observed between NLR and CRP (<jats:italic>r<\/jats:italic> = 0.322, <jats:italic>P<\/jats:italic> = 0.01). The patients receiving antitumor necrosis factor \u03b1 therapy had a lower NLR than the patients receiving nonsteroidal anti\u2010inflammatory drug therapy (mean NLR, 1.71 \u00b1 0.62 and 2.41 \u00b1 1.33, respectively, <jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NLR may be seen as a useful marker for demonstrating inflammation together with acute phase reactants such as CRP and in evaluating the effectiveness of anti\u2010TNF\u2010\u03b1 therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21768","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:06:45Z","timestamp":1400717205000},"page":"294-298","source":"Crossref","is-referenced-by-count":62,"title":["Neutrophil\u2013Lymphocyte Ratio Connected to Treatment Options and Inflammation Markers of Ankylosing Spondylitis"],"prefix":"10.1002","volume":"29","author":[{"given":"Ferhat","family":"G\u00f6kmen","sequence":"first","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Akbal","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Re\u015forlu","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"G\u00f6kmen","sequence":"additional","affiliation":[{"name":"Canakkale State Hospital  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem Bozkurt","family":"Aras","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Erba\u011f","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkam","family":"K\u00f6m\u00fcrc\u00fc","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Akbal","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Co\u015far","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University  Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_6_3_1","first-page":"980","article-title":"Relative value of erythrocyte sedimentation rate and C\u2010reactive protein in assessment of disease activity in ankylosing spondylitis","volume":"26","author":"Spoorenberg A","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_1","first-page":"971","article-title":"Clinical relevance of C\u2010reactive protein in axial involvement of ankylosing spondylitis","volume":"26","author":"Dougados M","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_1","first-page":"12","article-title":"Diagnosing ankylosing spondylitis","volume":"78","author":"Elyan M","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_1","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts. Rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R","year":"2001","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9675-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/185317"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.02.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.834498"},{"key":"e_1_2_6_11_1","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: The Bath Ankylosing Spondylitis Disease Activity Index","volume":"21","author":"Garrett S","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: The development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198101000-00002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(05)80003-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20329"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.07.005"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.21768","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.21768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:36:14Z","timestamp":1696541774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.21768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,21]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/jcla.21768"],"URL":"https:\/\/doi.org\/10.1002\/jcla.21768","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,21]]}}}