{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:37:56Z","timestamp":1694464676529},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T00:00:00Z","timestamp":1419552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Firat University Research Project Unit"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin resistance is found in both psoriasis and Beh\u00e7et's disease. No study has yet explored whether preptin and amylin, two hormones associated with insulin resistance, are involved in the insulin resistance observed in patients with psoriasis and Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to explore how the amounts of preptin and amylin change in psoriasis and Beh\u00e7et's disease and whether they are involved in the etiopathology of these two diseases, by comparing hormone levels in patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study registered 30 patients with psoriasis, 30 patients with Beh\u00e7et's disease, and 30 healthy volunteers (as a control group). Fasting blood sugar, triglyceride, LDL, VLDL, HDL, total cholesterol, HbA1c, C\u2010peptide, insulin, and serum preptin and amylin levels were measured in all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum preptin and amylin levels were significantly lower in the patients with psoriasis and Beh\u00e7et's disease than in the control group (<jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>P<\/jats:italic> = 0.004, and <jats:italic>P<\/jats:italic> = 0.008, respectively). A comparison of the serum preptin and amylin levels between the patients with psoriasis and Beh\u00e7et's disease did not reveal a statistically significant difference. Serum insulin level and The homeostasis model assessment of insulin resistance (HOMA\u2010IR) index were significantly lower in the psoriasis patient group relative to the control group (<jats:italic>P<\/jats:italic> = 0.02 and <jats:italic>P<\/jats:italic> = 0.03, respectively), while the values for the Beh\u00e7et's disease group did not differ significantly from those for the control group<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum levels of preptin and amylin were significantly lower in patients with psoriasis and Beh\u00e7et's disease, indicating that these hormones may be a factor for development of metabolic syndrome in these two diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21831","type":"journal-article","created":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T23:39:08Z","timestamp":1419637148000},"page":"165-168","source":"Crossref","is-referenced-by-count":7,"title":["Serum Preptin and Amylin Values in Psoriasis Vulgaris and Beh\u00e7et's Patients"],"prefix":"10.1002","volume":"30","author":[{"given":"Fatma Baskaya","family":"Dogan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Mehmet Akif Inan Education and Research Hospital  Sanliurfa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demet","family":"Cicek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Dermatology, Firat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Aydin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry, Firat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma Bakar","family":"Dertlioglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Dermatology, Firat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurhan","family":"Halisdemir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biostatistics, Firat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydar","family":"Ucak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Dermatology, Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Demir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Dermatology, Firat University  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilker","family":"Erden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Elazig Education and Research Hospital  Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120237"},{"key":"e_1_2_6_3_1","first-page":"118","article-title":"Insulin resistance and adiponectin levels in Beh\u00e7et's syndrome","volume":"25","author":"Oguz A","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01457.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07986.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3600431"},{"key":"e_1_2_6_7_1","first-page":"124","article-title":"A\u201d is for amylin and amyloid in type 2 diabetes mellitus","volume":"2","author":"Hayden 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