{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:11:13Z","timestamp":1788894673601,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic immune\u2010mediated inflammatory skin disease associated with increase of some pro\u2010inflammatory mediators. We wanted to investigate whether there is a relationship between psoriasis and visfatin, fetuin\u2010A and pentraxin 3 (PTX3)\u2014pro\u2010inflammatory mediators implicated in the development of insulin resistance (IR), metabolic syndrome, and atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Visfatin, fetuin\u2010A, and PTX3 concentrations were measured in 45 patients with plaque\u2010type psoriasis and 45 healthy controls using enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Serum<\/jats:italic> levels of visfatin, fetuin\u2010A, and PTX3 in patients with psoriasis were found to be higher than in healthy controls (<jats:italic>P<\/jats:italic> = 0.002, <jats:italic>P<\/jats:italic> = 0.009, <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). Psoriasis area and severity index (PASI) score correlated significantly with visfatin and fetuin\u2010A levels (<jats:italic>P<\/jats:italic> = 0.011, <jats:italic>P<\/jats:italic> = 0.040, respectively). There was a significant positive correlation between visfatin and fetuin\u2010A (<jats:italic>P<\/jats:italic> &lt; 0.001). PTX3 levels were correlated positively with homeostasis model assessment (HOMA\u2010IR), insulin, triglyceride (TG), and very low density lipoprotein cholesterol (VLDL; <jats:italic>P<\/jats:italic> = 0.009, <jats:italic>P<\/jats:italic> = 0.007, <jats:italic>P<\/jats:italic> = 0.023, <jats:italic>P<\/jats:italic> = 0.024, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased serum visfatin, fetuin\u2010A, and PTX3 levels, and the presence of positive correlation between visfatin, fetuin\u2010A, and PASI score, probably reflect the inflammatory state and IR seen in psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21850","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T15:07:07Z","timestamp":1428937627000},"page":"284-289","source":"Crossref","is-referenced-by-count":24,"title":["Serum Visfatin, Fetuin\u2010A, and Pentraxin 3 Levels in Patients With Psoriasis and Their Relation to Disease Severity"],"prefix":"10.1002","volume":"30","author":[{"given":"G\u00f6khan","family":"Okan","sequence":"first","affiliation":[{"name":"Dermatology Department, Kemerburgaz University  Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adile Merve","family":"Baki","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Biochemistry, Istanbul University  Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda","family":"Yorulmaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Park Bah\u00e7elievler Hospital  Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Do\u011fru\u2010Abbaso\u011flu","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Biochemistry, Istanbul University  Istanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pervin","family":"Vural","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Biochemistry, Istanbul University  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