{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T05:11:19Z","timestamp":1717218679332},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Klinefelter syndrome (KS) results from an extra chromosome X, which is due to the failure of normal chromosomal segregation during meiosis. Patients with KS have gynecomastia, small testes, and azoospermia. Apoptosis is a mechanism responsible for the normal regulation of spermatogenesis. <jats:italic>LDOC1<\/jats:italic> gene is a known regulator of nuclear factor mediated pathway to apoptosis through inhibition of nuclear factor kappa B (NF\u2010kappaB). Furthermore, the transcription factor myeloid zinc finger gene 1 (MZF\u20101) has been shown to interact with <jats:italic>LDOC1<\/jats:italic> and to enhance <jats:italic>LDOC1<\/jats:italic> activity favoring apoptosis. We investigated the expression of <jats:italic>LDOC1<\/jats:italic> gene mRNA, by quantitative reverse transcription polymerase chain reaction (qRT\u2010PCR), in peripheral blood leukocytes of 13 patients with KS compared to 13 healthy men chosen as controls. <jats:italic>LDOC1<\/jats:italic> expression was higher in 9 of the 13 KS patient compared to normal controls. These finding led us to hypothesize that <jats:italic>LDOC1<\/jats:italic> gene upregulation may play a role in the spermatogenesis derangement observed in patients with KS.<\/jats:p>","DOI":"10.1002\/jcla.21870","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T02:23:46Z","timestamp":1460600626000},"page":"408-410","source":"Crossref","is-referenced-by-count":2,"title":["<i>LDOC1<\/i> Gene Expression in Men With Klinefelter Syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"Michele","family":"Salemi","sequence":"first","affiliation":[{"name":"Oasi Institute (IRCCS) for Research on Mental Retardation and Brain Aging  Troina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosita A.","family":"Condorelli","sequence":"additional","affiliation":[{"name":"Section of Endocrinology,Andrology and Internal Medicine, Department of Medical and Pediatric Sciences University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusi","family":"Longo","sequence":"additional","affiliation":[{"name":"Laboratory Analysis, A.O.V. \u201cPoliclinico V. 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