{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:06:22Z","timestamp":1783011982349,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Staphylococci are one of the most common pathogens in nasocomial and community\u2010acquired infections. Methicillin\u2010resistant staphylococci are known to be resistant against all beta\u2010lactam antibiotics. Therefore, non\u2010beta\u2010lactam antibiotics such as macrolide and lincosamides can be used. Resistance to those antibiotics may lead to therapeutic failure. The purpose of the present study was to determine the prevalence of macrolide\u2013lincosamide\u2013streptogramin B (MLS<jats:sub>B<\/jats:sub>) resistance by using<jats:italic>D<\/jats:italic>\u2010test in staphylococcal isolates from various clinical samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one methicillin\u2010resistant Staphylococcus isolates (six<jats:italic>S. aureus<\/jats:italic>, 65 coagulase negative staphylococci) were included in this study. Staphylococci were identified with conventional methods. According to Clinical Laboratory Standards Institute (CLSI) criteria, susceptibility testing was performed by Kirby\u2013Bauer disk diffusion method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One of six (16.6%) methicillin\u2010resistant<jats:italic>S. aureus<\/jats:italic>isolates and 19 of 65 (29.2%) methicillin\u2010resistant coagulase\u2010negative staphylococci (MR\u2010CNS) were detected as<jats:italic>D<\/jats:italic>\u2010test positive. Twenty of 71 (28.1%) staphylococcal isolates detected as<jats:italic>D<\/jats:italic>\u2010test positive. Inducible clindamycin resistance was found at a higher rate in MR\u2010CNS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Since the resistant community and hospital acquired staphylococcal infections have become a therapeutic problem, it is very important to detect MLS<jats:sub>B<\/jats:sub>resistance routinely in microbiology laboratories.<jats:italic>D<\/jats:italic>\u2010test is a cheap and reliable diagnostic method that can be performed in every laboratory.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21884","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T09:13:06Z","timestamp":1445591586000},"page":"490-493","source":"Crossref","is-referenced-by-count":5,"title":["The Rate of Inducible MLS<sub>B<\/sub>Resistance in the Methicillin\u2010Resistant Staphylococci Isolated From Clinical Samples"],"prefix":"10.1002","volume":"30","author":[{"given":"T\u00fcrkan","family":"Toka \u00d6zer","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Mevlana University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"217","article-title":"Constitutive and inducible clindamycin resistance among nosocomially acqu\u0131red staphylococci","volume":"42","author":"Dizbay M","year":"2008","journal-title":"Mikrobiyol B\u00fcl"},{"key":"e_1_2_6_3_1","first-page":"102","article-title":"Stafilokok Su\u015flar\u0131nda macrolide\u2010lincozamide\u2010streptogramin B (MLSB) resistance phenotype","volume":"49","author":"Kart Ya\u015far K","year":"2011","journal-title":"Haseki T\u0131p B\u00fcl"},{"issue":"3","key":"e_1_2_6_4_1","first-page":"89","article-title":"Macrolide\u2010lincosamide\u2010streptogramin B (MLSB) resistance and fusidic acid susceptibility of methicillin resistant Staphylococcus aureus (MRSA) strains isolated from clinical samples","volume":"66","author":"Mert Din\u00e7 B","year":"2009","journal-title":"T\u00fcrk Hijyen ve Deneysel Biyoloji Der"},{"issue":"8","key":"e_1_2_6_5_1","first-page":"1620","article-title":"The prevalence of inducible and constitutive clindamycin resistance among the nasal isolates of staphylococci","volume":"7","author":"Mahesh CB","year":"2013","journal-title":"J Clin Diagn Res"},{"issue":"10","key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1128\/JCM.41.10.4740-4744.2003","article-title":"Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase\u2010negative staphylococci","volume":"41","author":"Fiebelkorn KR","year":"2003","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4176\/090128"},{"key":"e_1_2_6_8_1","unstructured":"Clinical Laboratory Standards Institute. 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