{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T15:08:23Z","timestamp":1721401703962},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Takayasu's arteritis (TAK) is a chronic, large\u2010vessel vasculitis. Vitamin D, as a steroidal hormone, has recently been shown to have immunoregulatory and immunosuppressive effects. Low vitamin D levels are demonstrated in various autoimmune disorders. The aim of this study is to investigate vitamin D levels in patients with TAK. A comprehensive review of vitamin D levels in systemic vasculitides (SVs) is also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 36 patients with TAK, 28 patients with Beh\u00e7et's disease (BD) as disease control and 30 sex\u2010matched healthy controls. Plasma 25\u2010hydroxy vitamin D (25(OH) vit D) levels were measured with high\u2010performance liquid chromatography. \u201cDeficiency\u201d was defined as 25(OH) vit D levels below 25 nmol\/l and \u201cinsufficiency\u201d as below 50 nmol\/l.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma 25(OH) vit D levels were significantly lower in TAK patients (16.93 \u00b1 10.62 nmol\/l) than healthy controls (64.63 \u00b1 21.82 nmol\/l). Vitamin D level in BD patients (38.8 \u00b1 20.9 nmol\/l) is lower than healthy controls but higher than TAK patients. The frequency of vitamin D deficiency was 83.3% in patients with TAK compared to 3.3% in healthy controls. Plasma 25(OH) vit D levels were same between clinically active and inactive patients. In literature review, very few studies were found to investigate vitamin D in SVs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a high prevalence of vitamin D deficiency in patients with TAK. As various immune effects of vitamin D on mononuclear cells and arterial endothelium is shown, vitamin D deficiency can be a predisposing factor for immune activation in SV. We therefore suggest monitorization and replacement of vitamin D status in all TAK and other SV patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21898","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T02:51:34Z","timestamp":1449975094000},"page":"529-533","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D Levels in Takayasu's Arteritis and a Review of the Literature on Vasculitides"],"prefix":"10.1002","volume":"30","author":[{"given":"Fatma","family":"Alibaz\u2010Oner","sequence":"first","affiliation":[{"name":"Department of Rheumatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Asmaz\u2010Haliloglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Gogas\u2010Yavuz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryem","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goncagul","family":"Haklar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2149-3"},{"issue":"1","key":"e_1_2_5_3_1","first-page":"S59","article-title":"Takayasu's arteritis in Turkey\u2014Clinical and angiographic features of 248 patients","volume":"27","author":"Bicakcigil M","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.020"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3730"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.05.026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.069831"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.044"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1678S"},{"issue":"4","key":"e_1_2_5_11_1","first-page":"S50","article-title":"Vitamin D modulates peripheral immunity in patients with Beh\u00e7et's disease","volume":"28","author":"Hamzaoui K","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(96)88783-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(96)02813-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9047"},{"issue":"3","key":"e_1_2_5_16_1","first-page":"S57","article-title":"Effect of vitamin D deficiency and replacement on endothelial functions in Beh\u00e7et's disease","volume":"30","author":"Can M","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.020"},{"key":"e_1_2_5_18_1","first-page":"506","article-title":"Pathogenesis of Takayasu's arteritis","volume":"14","author":"Noris M.","year":"2001","journal-title":"J Nephrol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.08.001"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117029"},{"key":"e_1_2_5_21_1","first-page":"1925","article-title":"Interferon\u2010gamma producing T cells in giant cell vasculitis represent a minority of tissue\u2010infiltrating cells and are located distant from the site of pathology","volume":"148","author":"Wagner AD","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.69.Suppl_2.SII40"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.872903"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4049\/jimmunol.133.4.1748","article-title":"1,25\u2010Dihydroxyvitamin D3 inhibits antigen\u2010induced T cell activation","volume":"133","author":"Bhalla AK","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240490106"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200002)30:2<498::AID-IMMU498>3.0.CO;2-Q"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.4974"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.06.002"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.007"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009193"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24790"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512442992"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311422094"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92277-8"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10398"},{"issue":"4","key":"e_1_2_5_36_1","first-page":"S13","article-title":"Vitamin D3 ameliorates herpes simplex virus\u2010induced Beh\u00e7et's disease\u2010like inflammation in a mouse model through down\u2010regulation of Toll\u2010like receptors","volume":"29","author":"Choi B","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.06.003"},{"issue":"5","key":"e_1_2_5_38_1","first-page":"721","article-title":"Vitamin D status in patients with Behcet's Disease","volume":"66","author":"Karatay S","year":"2011","journal-title":"Clinics (Sao Paulo)"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken109"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-13-18"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12153"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.10.010"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes209"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.07.003"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.12.004"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.01.001"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.21898","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.21898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:08:38Z","timestamp":1696367318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.21898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,10]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/jcla.21898"],"URL":"https:\/\/doi.org\/10.1002\/jcla.21898","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,10]]}}}