{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:34:08Z","timestamp":1767008048973},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic and recurrent inflammatory skin disease. Previous studies have shown that bilirubin has anti\u2010inflammation and antioxidant effects. However, the various roles of bilirubin in psoriasis patients are still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the serum total bilirubin (TB) level in the individuals with psoriasis vulgaris and further evaluate the relationship between serum TB concentration and C\u2010reactive protein (CRP) to clarify the effect of bilirubin on inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 214 patients with psoriasis vulgaris and 165 age\u2010 and gender\u2010matched healthy control subjects were recruited. The peripheral leukocyte count (<jats:italic>white blood cell<\/jats:italic>, WBC) and differential, serum biochemical and immunologic indexes including serum TB, immunoglobulin (Ig) G, IgA, IgM, complement C<jats:sub>3<\/jats:sub> and C<jats:sub>4<\/jats:sub>, as well as serum CRP concentrations were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that the serum TB level decreased significantly and peripheral WBC, neutrophil, and serum CRP concentrations increased significantly in patients with psoriasis vulgaris. Meanwhile, the serum CRP was negatively correlated with serum TB levels but positively correlated with peripheral WBC and the Psoriasis Area and Severity Index (PASI). Logistic regression analysis showed that the serum TB was a protective factor for psoriasis vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study suggests that lower serum TB is associated with the enhancement of the inflammatory response in psoriasis vulgaris. Therefore, lower serum TB has a prognostic significance for worsening psoriasis vulgaris. Bilirubin may play a crucial role in inflammation by contributing to the inhibition of the inflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21936","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:50:15Z","timestamp":1460310615000},"page":"768-775","source":"Crossref","is-referenced-by-count":27,"title":["Relationship Between the Serum Total Bilirubin and Inflammation in Patients With Psoriasis Vulgaris"],"prefix":"10.1002","volume":"30","author":[{"given":"Zhen\u2010Xing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Kui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Hospital Affiliated to Academy of Military Medical Science  Beijing P. R. 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