{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:22:18Z","timestamp":1789726938711,"version":"4.0.1"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>\u03b1\u2010Thalassemia is a benign condition that is often present in patients with diabetes mellitus. Here, we evaluated the effects of different genotypes \u03b1\u2010thalassemia on HbA<jats:sub>1c<\/jats:sub> measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 189 samples from nondiabetic patients were analyzed. HbA<jats:sub>1c<\/jats:sub> analysis was performed by ion\u2010exchange high\u2010performance liquid chromatography, boronate affinity HPLC, immunoassay, and capillary electrophoresis. Fasting glucose, fructosamin, and HbA<jats:sub>2<\/jats:sub> were also performed. All samples were confirmed by genotyping for thalassemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with two or three functional \u03b1\u2010genes, HbA<jats:sub>1c<\/jats:sub> values were not significantly different from those of controls (<jats:italic>P<\/jats:italic> &gt; 0.05); however, in individuals with \u03b1\u2010thalassemia with one functional \u03b1\u2010gene (i.e., HbH disease), HbA<jats:sub>1c<\/jats:sub> levels were significantly different from those of controls (<jats:italic>P<\/jats:italic> &lt; 0.01). HbA<jats:sub>1c<\/jats:sub> values were significantly lower in individuals with HbH disease than in control individuals and patients in the other two \u03b1\u2010thalassemia groups. For patients with HbH disease, there were no significant differences in the four HbA<jats:sub>1c<\/jats:sub> measurement systems (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, HbA<jats:sub>1c<\/jats:sub> values in samples from individuals with two or three functional \u03b1\u2010genes basically reflected the normal mean blood glucose level, while those in samples from individuals with one functional \u03b1\u2010gene did not.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21983","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T06:03:37Z","timestamp":1463465017000},"page":"1078-1080","source":"Crossref","is-referenced-by-count":14,"title":["Effects of \u03b1\u2010Thalassemia on HbA<sub>1c<\/sub> Measurement"],"prefix":"10.1002","volume":"30","author":[{"given":"Anping","family":"Xu","sequence":"first","affiliation":[{"name":"Clinical Medical Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ji","sequence":"additional","affiliation":[{"name":"Clinical Medical Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Medical Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[{"name":"Clinical Medical Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Medical Laboratory Peking University Shenzhen Hospital Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.103580"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-1134"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-905"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.3.436"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.103580"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.01.004"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.07.015"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S011"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.21983","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.21983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:18:44Z","timestamp":1696367924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.21983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/jcla.21983"],"URL":"https:\/\/doi.org\/10.1002\/jcla.21983","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}