{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:36:37Z","timestamp":1724416597669},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We previously showed that glycated albumin (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) is a useful glycemic control indicator in patients with neonatal diabetes mellitus (<jats:styled-content style=\"fixed-case\">NDM<\/jats:styled-content>), and that age\u2010adjusted <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) can reflect more accurately glycemic control status. Here, we investigated whether the age at diagnosis influences Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis of <jats:styled-content style=\"fixed-case\">NDM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight patients with <jats:styled-content style=\"fixed-case\">NDM<\/jats:styled-content> whose <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> was measured at diagnosis (age at diagnosis: 39 \u00b1 18 days; <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>: 31.3 \u00b1 7.6%; Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>: 47.1 \u00b1 10.3%; plasma glucose: 525 \u00b1 194 mg\/dl) were included. Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> was calculated as follows: Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> = <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> \u00d7 14.0\/[1.77 \u00d7 log\u2010age (days) + 6.65]. Correlations of <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> or Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis with its logarithmically transformed age in days (log\u2010age), plasma glucose, and their product were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis was not significantly correlated with log\u2010age or plasma glucose. On the other hand, Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis was significantly positively correlated with plasma glucose (<jats:italic>R<\/jats:italic> = 0.75, <jats:italic>P<\/jats:italic> = 0.031) and was more strongly positively correlated with the product of plasma glucose and log\u2010age (<jats:italic>R<\/jats:italic> = 0.82, <jats:italic>P<\/jats:italic> = 0.012) although it was not correlated with log\u2010age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aa\u2010<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> at diagnosis is influenced by both age in days and plasma glucose. This finding is likely to show the aspect that age in days is almost equal to diabetes duration because glycemic control indicators including <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> reflect the weighted mean of plasma glucose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21985","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T09:04:25Z","timestamp":1461834265000},"page":"1086-1091","source":"Crossref","is-referenced-by-count":1,"title":["Age\u2010Adjusted Glycated Albumin at Diagnosis is more Correlated with the Product of Age and Plasma Glucose than Plasma Glucose Alone in Patients with Neonatal Diabetes Mellitus"],"prefix":"10.1002","volume":"30","author":[{"given":"Akiko","family":"Furuya","sequence":"first","affiliation":[{"name":"Department of Pediatrics Asahikawa Medical University Asahikawa 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