{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:32:43Z","timestamp":1789338763770,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study is to elucidate the association between <jats:italic>\u03b1\u2010synuclein<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content><\/jats:italic>) polymorphisms and the risk of Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> was applied to detect <jats:italic><jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content><\/jats:italic> gene rs6532190, rs3775430, and rs10516846 polymorphisms in 98 <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients and 105 healthy elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> frequency of rs10516846 was evidently increased in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group than control group (<jats:italic>P<\/jats:italic> &lt; 0.05). There was a significant difference in <jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content> level between the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and control groups (<jats:italic>P<\/jats:italic> &lt; 0.01). In the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group, the <jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content> level in cerebrospinal fluid of <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> (rs10516846) carriers was increased as compared with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> carriers (<jats:italic>P<\/jats:italic> &lt; 0.05). The <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> (rs10516846) frequency of the early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group is significantly higher than that of the late\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group (<jats:italic>P<\/jats:italic> &lt; 0.05). The frequency of rs3775430 <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> was lower in the early\u2010onset group than that in the late\u2010onset group (0% vs. 16.7%). The <jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content> level in cerebrospinal fluid of <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> (rs10516846) carriers in the early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> group is higher than that of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> carriers (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content><\/jats:italic> gene polymorphism may be associated with an increased risk of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype of rs10516846 and elevated <jats:styled-content style=\"fixed-case\">SNCA<\/jats:styled-content> level in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> may increase the risk of early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21986","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T06:03:40Z","timestamp":1463465020000},"page":"1092-1099","source":"Crossref","is-referenced-by-count":32,"title":["<i><scp>SNCA<\/scp><\/i> Gene Polymorphism may Contribute to an Increased Risk of Alzheimer's Disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Quanbao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Linyi People's Hospital Linyi Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology Linyi People's Hospital Linyi Shandong Province 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