{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:16:31Z","timestamp":1781914591026,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lupus nephritis is a serious manifestation of systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>). The objective of this study was to identify the sensitivity, specificity, and cut\u2010off values of <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 in the serum and urine of patients with lupus nephritis compared to renal biopsy, albumin\/creatinine ratio, and serum anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty female <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients were included. <jats:styled-content style=\"fixed-case\">SLEDAI<\/jats:styled-content> was calculated and blood and urine samples were collected. Patients were divided into 10 <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients with renal involvement (six active and four inactive), 10 active <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, and 10 inactive <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients. Ten age\u2010matched healthy (control) were included. Serum and urinary levels of <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, urine albumin\/creatinine ratio were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum and urinary <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 in active <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients had significantly increased levels as compared to inactive <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic> = 0.015, <jats:italic>P<\/jats:italic> = 0.033, respectively). However, there was no difference in serum and urinary levels between active renal and active non\u2010renal patients. Albumin\/creatinine ratio is a better marker in differentiating between lupus nephritis and <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> with no renal involvement. Any of serum and urinary <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010, albumin\/creatinine ratio, and anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> did not correlate with the class of lupus nephritis in renal biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urinary and serum <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 are useful markers of lupus activity, but not indicative of renal activity. Albumin\/creatinine ratio is superior in identifying lupus nephritis and renal activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21993","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T06:03:43Z","timestamp":1463465023000},"page":"1135-1138","source":"Crossref","is-referenced-by-count":27,"title":["Serum and Urinary Interferon\u2010Gamma\u2010Inducible Protein 10 in Lupus Nephritis"],"prefix":"10.1002","volume":"30","author":[{"given":"Ahmed","family":"El\u2010Gohary","sequence":"first","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Abbas","sequence":"additional","affiliation":[{"name":"Community medicine and Public Health Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8990-2312","authenticated-orcid":false,"given":"Noha","family":"Kamel","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah Ismail","family":"Nasef","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21224"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2057oa"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.04.008"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/638413"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313484977"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(97)00015-4"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63152-5"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/589471"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-333"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0757"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu467oa"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.02.008"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.038315"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03880.x"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24803"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.21993","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.21993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:17:30Z","timestamp":1696367850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.21993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/jcla.21993"],"URL":"https:\/\/doi.org\/10.1002\/jcla.21993","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}