{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:56:00Z","timestamp":1762761360775},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/13\/71\/2008\u2010NCD\u2010III"],"award-info":[{"award-number":["5\/13\/71\/2008\u2010NCD\u2010III"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cyclooxygenase\u20102 (Cox\u20102) is frequently overexpressed in cervical carcinoma, but little is known about its altered serum concentration. Hence, this study evaluates clinical utility of cellular and serum level of Cox\u20102 enzyme in cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression of Cox\u20102 was evaluated in cervical tissues and serum samples collected from normal controls (<jats:italic>n<\/jats:italic> = 100; <jats:italic>n<\/jats:italic> = 68), cervical intraepithelial neoplasia patients (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 67; <jats:italic>n<\/jats:italic> = 12), and invasive squamous cell carcinoma patients (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s; <jats:italic>n<\/jats:italic> = 153; <jats:italic>n<\/jats:italic> = 127) by immunohistochemical and enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The significant cytoplasmic overexpression of Cox\u20102 was noted in 50.7% of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> and 69.9% of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s as compared with normal (<jats:italic>P<\/jats:italic> = 0.0001). Serum level of Cox\u20102 was also found to be elevated both in <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> (median 4.35 ng\/ml) and in <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s (median 19.39 ng\/ml) with respect to normal (median 0.44 ng\/ml; <jats:italic>P<\/jats:italic> = 0.0001), respectively. The <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis revealed the potential of serum Cox\u20102 over its cellular expression to distinguish <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s from normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Augmented Cox\u20102 activity is implicated in the pathogenesis of cervical cancer, and its serum level could serve a potential to distinguish this malignancy. Therefore, it is suggested that serum Cox\u20102 may be useful in monitoring the diagnosis and treatment outcome of patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22003","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T06:13:25Z","timestamp":1465798405000},"page":"1198-1207","source":"Crossref","is-referenced-by-count":8,"title":["Augmented Activity of Cyclooxygenase\u20102 in Tissue and Serum of Patients With Cervical Cancer"],"prefix":"10.1002","volume":"30","author":[{"given":"Poonam","family":"Jawanjal","sequence":"first","affiliation":[{"name":"Department of Anatomy Vardhman Mahavir Medical College &amp; Safdarjung Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Salhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Vardhman Mahavir Medical College &amp; Safdarjung Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indrani","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Department of Histopathology Vardhman Mahavir Medical College &amp; Safdarjung Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmalendu","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Vardhman Mahavir Medical College &amp; Safdarjung Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Anatomy Vardhman Mahavir Medical College &amp; Safdarjung Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics &amp; Biochemistry Institute of Cytology and Preventive Oncology (ICPO) ICMR Noida India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayatri","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Anatomy Vardhman Mahavir Medical College &amp; Safdarjung Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al.GLOBOCAN 2012 v 1.0 Cancer Incidence and Mortality Worldwide. 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