{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:26:31Z","timestamp":1766427991644},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T00:00:00Z","timestamp":1466899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Risperidone (<jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content>) is a widely used atypical antipsychotic drug. We developed and validated a sensitive and accurate <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> method, which requires a small\u2010volume of plasma and small\u2010volume injection for measurement of <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> levels in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> pediatric patients. We also investigated the relationship between <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> dosages, including prolactin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Blood samples were processed by protein precipitation extraction. Only 1 \u03bcl of sample was injected. Plasma samples were separated on a C18 column (4.6 cm \u00d7 50 mm; 1.8 \u03bcm particle size). Detection was by <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> with an analytical run time of 6 min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The inter\u2010day accuracy of <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> was 101.33\u2013107.68% and 95.24\u2013103.67% for 9\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content>. The inter\u2010day precision of <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> was \u22647.27% <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> and \u22647.41% <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> for 9\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content>. The extraction recovery of <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> and 9\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> were 95.01 \u00b1 7.31\u2013112.62 \u00b1 7.50% and 90.27 \u00b1 11.15\u2013114.00 \u00b1 10.35%, respectively. This method was applied in the therapeutic drug monitoring of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> pediatric patients. Higher <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> dosage has a tendency to produce higher <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> plasma levels. The high <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> plasma levels have a tendency to produce hyperprolactinemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The determination of <jats:styled-content style=\"fixed-case\">RIS<\/jats:styled-content> in individual patients might be clinically useful for monitoring and prediction of treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22009","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T04:44:26Z","timestamp":1467002666000},"page":"1236-1246","source":"Crossref","is-referenced-by-count":22,"title":["Development and Validation of Liquid Chromatography\/Tandem Mass Spectrometry Analysis for Therapeutic Drug Monitoring of Risperidone and 9\u2010Hydroxyrisperidone in Pediatric Patients with Autism Spectrum 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