{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:17:29Z","timestamp":1762867049523,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to investigate the serum levels of procalcitonin and its association with autoantibodies in patients with euthyroid Hashimoto's thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 80 participants were included in the study; 40 of which were newly diagnosed with Hashimoto's thyroiditis, aged over 18, and 40 of which were healthy volunteers. The serum levels of procalcitonin were measured by enzyme\u2010linked immunosorbent assay kit. Thyroid function tests were analyzed in hormone laboratory with Electro\u2010chemiluminescence immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hashimoto's thyroiditis patients had higher median procalcitonin levels than those of the control group (34.3\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> vs 27.8\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> respectively; <jats:italic>P<\/jats:italic>=.037). Also, male patients had higher median procalcitonin levels as compared to female patients (37\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> vs 27\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> respectively; <jats:italic>P<\/jats:italic>=.013). In the Hashimoto's thyroiditis group, procalcitonin level was positively correlated with anti\u2010thyroglobulin and anti\u2010thyroid peroxidase levels (<jats:italic>r=<\/jats:italic>.559, <jats:italic>P<\/jats:italic>&lt;.001; <jats:italic>r<\/jats:italic>=634, <jats:italic>P<\/jats:italic>&lt;.001, respectively). The procalcitonin and anti\u2010thyroid peroxidase levels were identified to be an independent predictor in diagnosis of Hashimoto's thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The fact that procalcitonin was found to be correlated with thyroid autoantibodies and found to be an independent risk factor for Hashimoto's thyroiditis in the regression analysis in the framework of this study urges us to think that procalcitonin may be associated with the autoimmunity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22123","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T19:38:43Z","timestamp":1486496323000},"source":"Crossref","is-referenced-by-count":2,"title":["The relationship between procalcitonin and thyroid autoantibodies in patients with autoimmune thyroiditis"],"prefix":"10.1002","volume":"31","author":[{"given":"Ali","family":"Oncul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihsan","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Fettah","family":"Arikan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisbet","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Topcuoglu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Meric","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Altay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ankara Numune Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.6.1700"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-1061"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.424"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80068-9"},{"key":"e_1_2_6_6_1","article-title":"The role of circulating 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