{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:15:28Z","timestamp":1790626528275,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension (<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content> in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of current study was to explore whether biochemical and hematological parameters are associated with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content> in a cohort study with a 7\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (<jats:styled-content style=\"fixed-case\">MASHAD<\/jats:styled-content>) cohort study, and biochemical and hematological factors were measured in all subjects. Univariate and multivariate logistic regression analysis were performed to determine the association of biochemical and hematological parameters with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several biochemical parameters including fasting plasma glucose (<jats:styled-content style=\"fixed-case\">FBG<\/jats:styled-content>), serum high\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), triglyceride (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>), total cholesterol (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>), low\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C), and uric acid were increased in hypertensive participants. In contrast, serum high\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C) was lower in hypertensive individuals. Furthermore, we demonstrated that hematological parameters including white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) count, red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) count, hemoglobin (<jats:styled-content style=\"fixed-case\">HGB<\/jats:styled-content>), hematocrit (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>), and mean corpuscular hemoglobin (<jats:styled-content style=\"fixed-case\">MCH<\/jats:styled-content>) were higher in the hypertensive group compared to the control group. But mean corpuscular volume (<jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>), and red cell distribution width (<jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>), were decreased in the hypertensive group. Furthermore, our results strongly suggested that among these parameters, hematocrit was the independent risk factor for hypertension in the population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated the association of altered biochemical and hematological factors with hypertension supporting the value of emerging markers for early prediction of high blood pressure in prone individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22124","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T15:51:30Z","timestamp":1484927490000},"source":"Crossref","is-referenced-by-count":80,"title":["Association of hematocrit with blood pressure and hypertension"],"prefix":"10.1002","volume":"31","author":[{"given":"Marzieh","family":"Emamian","sequence":"first","affiliation":[{"name":"Metabolic Syndrome Research Center School of Medicine Mashhad University of Medical Sciences  Mashhad 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