{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:27:19Z","timestamp":1768566439567,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:00Z","timestamp":1487376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673181"],"award-info":[{"award-number":["81673181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>The insulin\u2010like growth factor (IGF<\/jats:styled-content><\/jats:italic>) pathway was involved in the occurrence of spontaneous preterm birth (SPTB<\/jats:styled-content>), but little is known regarding the relationship between genetic variations in IGF<\/jats:styled-content> pathway and the risk of SPTB<\/jats:styled-content>. We aimed to investigate the associations of IGF<\/jats:styled-content>1<\/jats:italic> rs972936 and IGF<\/jats:styled-content>1<\/jats:italic> receptor (IGF<\/jats:styled-content>1R<\/jats:italic>) rs2229765 polymorphisms with SPTB<\/jats:styled-content> risk in a Chinese population.<\/jats:p><\/jats:sec>Method<\/jats:title>A total of 114 cases of SPTB<\/jats:styled-content> and 250 controls of term delivery were included from Guangzhou Women and Children's Medical Center, China. The odds ratios (OR<\/jats:styled-content>s) and the corresponding 95% confidence intervals (CI<\/jats:styled-content>s) were calculated using multivariate logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>We found that the GA<\/jats:styled-content> and GA<\/jats:styled-content>\/AA<\/jats:styled-content> genotypes of IGF<\/jats:styled-content>1<\/jats:italic> rs972936 were associated with an increased risk of SPTB<\/jats:styled-content>, and the adjusted OR<\/jats:styled-content>s (95% CI<\/jats:styled-content>) were 1.74 (1.01\u20103.02) and 1.75 (1.04\u20102.93) respectively. Women carrying GA<\/jats:styled-content> and GA<\/jats:styled-content>\/AA<\/jats:styled-content> genotypes of IGF<\/jats:styled-content>1R<\/jats:italic> rs2229765 had a reduced risk compared to those with the GG<\/jats:styled-content> genotype (0.60 [0.37\u20100.98] and 0.64 [0.40\u20101.00] respectively). There were significant interactions between IGF<\/jats:styled-content>1<\/jats:italic> rs972936 and GDM<\/jats:styled-content> status (P<\/jats:italic> for interaction=.02), as well as between IGF<\/jats:styled-content>1R<\/jats:italic> rs2229765 and pre\u2010pregnancy BMI<\/jats:styled-content> (P<\/jats:italic> for interaction <.001) on the risk of SPTB<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings suggest that polymorphisms of IGF<\/jats:styled-content>1<\/jats:italic> rs972936 and IGF<\/jats:styled-content>1R<\/jats:italic> rs2229765 were associated with the risk of SPTB<\/jats:styled-content> in Chinese pregnant women and these effects depend on the maternal metabolic status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22125","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T08:42:45Z","timestamp":1487407365000},"source":"Crossref","is-referenced-by-count":15,"title":["Maternal IGF<\/scp>1 and IGF<\/scp>1R polymorphisms and the risk of spontaneous preterm birth"],"prefix":"10.1002","volume":"31","author":[{"given":"Jian\u2010Rong","family":"He","sequence":"first","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Mian","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Yan","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Shu","family":"Kuang","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian\u2010Nian","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and 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