{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:23Z","timestamp":1791499523844,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n Background<\/jats:title>\n Functions, morphology, distributions, and index of the circulating cells are the most useful parameters that indicate various inflammatory and toxic conditions. The aim of this study was to investigate the clinical significance of these parameters in patients diagnosed with (synthetic) cannabis use disorder.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study included a total of 40 patients in the study group (\n SG<\/jats:styled-content>\n ) with synthetic cannabis use; and 40 healthy individuals as the control group (\n CG<\/jats:styled-content>\n ). Participants, who had hematological disorders and other chronic diseases, were excluded from the study. All hematological parameters of\n SG<\/jats:styled-content>\n were compared with\n CG<\/jats:styled-content>\n . Neutrophil\/lymphocyte ratio (\n NLR<\/jats:styled-content>\n ) and platelet\/lymphocyte ratio (\n PLR<\/jats:styled-content>\n ) values were calculated and compared between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were statistically significant differences between the groups in terms of\n WBC<\/jats:styled-content>\n ,\n MCH<\/jats:styled-content>\n ,\n RDW<\/jats:styled-content>\n ,\n MCV<\/jats:styled-content>\n ,\n MPV<\/jats:styled-content>\n , and\n NEU<\/jats:styled-content>\n ,\n LYM<\/jats:styled-content>\n %,\n MONO<\/jats:styled-content>\n % parameters (\n P<\/jats:italic>\n <.05).\n MPW<\/jats:styled-content>\n and\n LYM<\/jats:styled-content>\n % were significantly lower in\n SG<\/jats:styled-content>\n compared to\n CG<\/jats:styled-content>\n .\n WBC<\/jats:styled-content>\n ,\n MCH<\/jats:styled-content>\n ,\n RDW<\/jats:styled-content>\n ,\n MCV<\/jats:styled-content>\n ,\n MPV<\/jats:styled-content>\n ,\n MONO<\/jats:styled-content>\n , and\n NEU<\/jats:styled-content>\n parameters were significantly higher in\n SG<\/jats:styled-content>\n compared to\n CG<\/jats:styled-content>\n (\n P<\/jats:italic>\n <.05).\n UIBC<\/jats:styled-content>\n and\n TIBC<\/jats:styled-content>\n levels were significantly higher in\n SG<\/jats:styled-content>\n compared to\n CG<\/jats:styled-content>\n (\n P<\/jats:italic>\n <.001). Although there was statistically significant difference between groups in terms of\n NLR<\/jats:styled-content>\n , there was no significant difference for\n PLR<\/jats:styled-content>\n values.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our data suggested that chronic use of cannabinoids can lead to deterioration of hematopoietic cells. Chronic use of cannabinoids was consistent with subthreshold\/subclinical megaloblastic anemia with iron deficiency. Inflammatory cells, especially neutrophil and monocyte counts were higher in\n SG<\/jats:styled-content>\n compared to\n CG<\/jats:styled-content>\n . Thus, recovery of subclinical hematological parameters should be considered in cannabis use disorder patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.22131","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T05:07:09Z","timestamp":1486444029000},"source":"Crossref","is-referenced-by-count":35,"title":["Alterations of the hematologic cells in synthetic cannabinoid users"],"prefix":"10.1002","volume":"31","author":[{"given":"Derya","family":"Guzel","sequence":"first","affiliation":[{"name":"Department of Physiology Medical Faculty Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Bulent","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Sakarya Research & Training Hospital Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical Faculty Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atila","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical Faculty Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1367.024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.10.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00060"},{"key":"e_1_2_8_7_1","unstructured":"(National Institute on Drug Abuse (NIH).DrugFacts: Synthetic Cannabinoids \u201cWhat are synthetic cannabinoids?\u201d.2015.https:\/\/www.drugabuse.gov\/publications\/drugfacts\/synthetic-cannabinoids. Accessed June 10 2016."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.08.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.10.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association(APA)","year":"2013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1110590"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S89417"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707442"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2013.03.041"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0031-6997(25)06895-4","article-title":"General pharmacological actions of some synthetic tetrahydrocannabinol derivatives","volume":"23","author":"Hardman HF","year":"1971","journal-title":"Pharmacol Rev"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385952-5.00004-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0342"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.10.3605"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409000957"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.050"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2015.5843"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2011.831"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0704"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037644"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.08.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080240"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795049804"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-014-0560-2"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.10.003"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2013.130501"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2013.766923"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.01.034"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1149054"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.20452\/pamw.1284","article-title":"Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease","volume":"122","author":"Ulasli SS","year":"2012","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2013.803530"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067688"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121971"},{"key":"e_1_2_8_40_1","first-page":"483","article-title":"Analysis of the inflammation reaction and selected indicators of immunity in patients with an infected diabetic ulcer","volume":"141","author":"Jirkovska A","year":"2002","journal-title":"Cas Lek Cesk"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.657"},{"key":"e_1_2_8_42_1","first-page":"507","article-title":"Venous endothelial damage produced by massive sticking and emigration of leukocytes","volume":"74","author":"Stewart GJ","year":"1974","journal-title":"Am J Pathol"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4513"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.006"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.59931"},{"key":"e_1_2_8_46_1","first-page":"BC11","article-title":"Effect of intensity of cigarette smoking on hematological and lipid parameters","volume":"8","author":"Anandha Lakshmi S","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108282"},{"key":"e_1_2_8_48_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1182\/asheducation-2009.1.153","article-title":"Drug\u2010induced thrombocytopenia: pathogenesis, evaluation, and management","volume":"1","author":"George JN","year":"2009","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260040045023"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000466"},{"key":"e_1_2_8_51_1","first-page":"82","article-title":"Effect of marijuana smoking on some hematological parameters of smokers","volume":"1","author":"Oseni BS","year":"2006","journal-title":"World J Med Sci"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1296"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.07.109"},{"key":"e_1_2_8_54_1","first-page":"145619","article-title":"Elevated red blood cell distribution width as a simple prognostic factor in patients with symptomatic multiple myeloma","volume":"2014","author":"Lee H","year":"2014","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.4.3.236"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T22:38:10Z","timestamp":1749940690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,7]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/jcla.22131"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22131","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,7]]},"article-number":"e22131"}}