{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:09:35Z","timestamp":1774512575163,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>To discover how NLRP<\/jats:styled-content>3<\/jats:italic> and TNFRSF<\/jats:styled-content>1A<\/jats:italic> polymorphisms affect the efficacy of traditional medicine and etanercept for ankylosing spondylitis (AS<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Single nucleotide polymorphism (SNP<\/jats:styled-content>) and haplotype analyses were conducted based on determined NLRP<\/jats:styled-content>3<\/jats:italic> and TNFRSF<\/jats:styled-content>1A<\/jats:italic> among AS<\/jats:styled-content> patients. We subsequently analyzed the relationship between relevant clinical indexes and polymorphisms of NLRP<\/jats:styled-content>3<\/jats:italic> and TNFRSF<\/jats:styled-content>1A<\/jats:italic>.<\/jats:p><\/jats:sec>Results<\/jats:title>The 4 SNP<\/jats:styled-content> loci on NLRP<\/jats:styled-content>3<\/jats:italic> and 3 SNP<\/jats:styled-content> loci on TNFRSF<\/jats:styled-content>1A<\/jats:italic> showed significant linkage disequilibrium, respectively. The T allele of NLRP<\/jats:styled-content>3<\/jats:italic> rs4612666 and the T allele of TFRSF<\/jats:styled-content>1A<\/jats:italic> rs4149570 are both associated with AS<\/jats:styled-content> (P<\/jats:italic><.05). The T\u2010A\u2010C\u2010T haplotype of NLRP<\/jats:styled-content>3 as well as the G\u2010C\u2010C, T\u2010C\u2010C, T\u2010C\u2010T, and T\u2010T\u2010T haplotypes of TFRSF<\/jats:styled-content>1A are associated with AS<\/jats:styled-content> (P<\/jats:italic><.05). The morning stiffness time, BASDAI<\/jats:styled-content> scoring, and ESR<\/jats:styled-content> of patients receiving etanercept were significantly higher than those receiving traditional medicine. T allele of NLRP<\/jats:styled-content>3<\/jats:italic> rs4612666 had a significantly greater negative impact on the ASAS<\/jats:styled-content>20 improvement than C allele. Whereas the A allele of NLRP<\/jats:styled-content>3<\/jats:italic> rs3806268 had a significantly greater positive impact on the ASAS<\/jats:styled-content>20 improvement than G allele. There is no significant association between SNP<\/jats:styled-content> and efficacy of traditional medicine in the treatment of AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>NLRP<\/jats:styled-content>3<\/jats:italic> and TFRSF<\/jats:styled-content>1A<\/jats:italic> (rs4149570) are associated with AS<\/jats:styled-content> susceptibility. There is a significant association between NLRP<\/jats:styled-content>3<\/jats:italic> polymorphisms and treatment of etanercept.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22138","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T04:58:16Z","timestamp":1485233896000},"source":"Crossref","is-referenced-by-count":29,"title":["The association of NLRP3<\/i> and TNFRSF1A<\/i> polymorphisms with risk of ankylosing spondylitis and treatment efficacy of etanercept"],"prefix":"10.1002","volume":"31","author":[{"given":"Shengchun","family":"Zhao","sequence":"first","affiliation":[{"name":"Second Department of Orthopaedics Yiwu City Central Hospital Yiwu Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Yiwu City Central Hospital Yiwu Zhejiang 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