{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:19Z","timestamp":1753869379740,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of sickle cell trait is extremely high in sub\u2010Saharan Africa. Recent studies have reported the impact of sickle cell carriers on renal function. However, data on renal abnormalities in children with sickle cell trait in this part of the world are unknown. In this report, we assess the glomerular function of children with sickle cell trait (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case control study was conducted to assess the glomerular function in 43 Congolese children with sickle cell trait (Hb\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) matched for age to 65 children with sickle cell anemia in steady state (Hb\u2010<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) and 67 normal controls (Hb\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference in the blood pressure levels between the Hb\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> group vs Hb\u2010<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>&lt;.05). The estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) corrected for body surface area was increased in Hb\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> group compared to Hb\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> group, but there was no significant difference between the two groups (<jats:italic>P<\/jats:italic>=.48). At the same time, the <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> was decreased, but no significantly so, in the Hb\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> group compared to the Hb\u2010<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>=.19). The proportion of children with Hb\u2010<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> (16.3%) who had hyperfiltration was higher compared to the proportion (6.1%) found in the Hb\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> group, but lower compared to the proportion found in the Hb\u2010<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group (30%). However, in both situations, the difference was not statistically significant. No case of proteinuria was detected in children with Hb\u2010AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It appears that at least one of six children with <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> had hyperfiltration. The findings could form a basis for further studies on this renal physiology among <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> individuals in Africa.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22143","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T12:50:29Z","timestamp":1484830229000},"source":"Crossref","is-referenced-by-count":6,"title":["Congolese children with sickle cell trait may exhibit glomerular hyperfiltration: A case control study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-1170","authenticated-orcid":false,"given":"Michel Ntetani","family":"Aloni","sequence":"first","affiliation":[{"name":"Division of Hemato\u2010oncology and nephrology Department of Paediatrics School of Medicine University Hospital of Kinshasa University of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 Makwala","family":"Ngiyulu","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010oncology and nephrology Department of Paediatrics School of Medicine University Hospital of Kinshasa University of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lestin Ndosimao","family":"Nsibu","sequence":"additional","affiliation":[{"name":"Intensive Care Division Department of Paediatrics School of Medicine University Hospital of Kinshasa University of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9p\u00e9 Mfutu","family":"Ekulu","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010oncology and nephrology Department of Paediatrics School of Medicine University Hospital of Kinshasa University of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Robert","family":"Makulo","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Internal Medicine School of Medicine University Hospital of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Lambert","family":"Gini\u2010Ehungu","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010oncology and nephrology Department of Paediatrics School of Medicine University Hospital of Kinshasa University of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazaire Mangani","family":"Nseka","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Internal Medicine School of Medicine University Hospital of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois Bompeka","family":"Lepira","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis Department of Internal Medicine School of Medicine University Hospital of Kinshasa  Kinshasa Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"415","volume-title":"Sickle cell disease","author":"Serjeant GR","year":"1992"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70150-5"},{"key":"e_1_2_9_5_1","first-page":"1155","article-title":"Centers for Disease Control and Prevention (CDC). 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