{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:16Z","timestamp":1753869376588,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low value of serum Clara cell protein (CC16) is associated with bronchial hyperreactivity in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the serum CC16 in relation to atopy and previously manifested LRTD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the population of 163 healthy 5\u2010 to 24\u2010month\u2010old children, atopy was determined by Phadiatop\u2010infant (serum\u2010specific IgE\u22650.35\u00a0kUA\/L), serum CC16 by ELISA, while data on previously manifested low respiratory tract diseases (LRTD) were collected from the Health Care Center database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In atopic children, serum CC16 negatively correlated with age (<jats:italic>r<\/jats:italic> \u2212.281, <jats:italic>P<\/jats:italic>=.041, n=53), while in nonatopic children, this correlation was positive (<jats:italic>r<\/jats:italic> .200, <jats:italic>P<\/jats:italic>=.036, n=110). Atopic \u22658\u2010month\u2010old children with previously manifested LRTD had lower level of CC16 (3.07\u00a0ng\/mL) in relation to atopic children without LRTD at the same age (6.51\u00a0ng\/mL), <jats:italic>P<\/jats:italic>=.029 (value of serum CC16\u22654.8\u00a0ng\/mL indicates atopic phenotype without LRTD 75% sensitivity, 87.5% specificity). In 8\u2010 to 24\u2010month\u2010old children with previously manifested pneumonia, serum CC16 was lower in atopic (2.9\u00a0ng\/mL) in relation to nonatopic children (3.7\u00a0ng\/mL), <jats:italic>P<\/jats:italic>=.029 (serum CC16 \u22643.4\u00a0ng\/mL indicating atopy in the group of children with pneumonia, sensitivity 100%, and specificity 77%). Atopic 8\u2010 to 24\u2010month\u2010old children with previously manifested pneumonia had lower CC16 in relation to other atopic children in this age (<jats:italic>P<\/jats:italic>=.021) (for cutoff CC16\u22643.4\u00a0ng\/mL sensitivity 100%, specificity 77%), and also often chronic wheezing (atopic with pneumonia 83.3%, n=5\/6 vs atopic without pneumonia 21.4%, n=3\/14), <jats:italic>P<\/jats:italic>=.018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low serum CC16 is associated with previously expressed pneumonia and chronic wheezing in atopic children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22151","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T14:55:30Z","timestamp":1485960930000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum Clara cell protein and atopic phenotype in children up to 2\u00a0years of age"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-942X","authenticated-orcid":false,"given":"Nevenka","family":"Ilic","sequence":"first","affiliation":[{"name":"Department of Allergology and Immunology Public Health Institute  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Mihailovic","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Public Health Institute  Kragujevac 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