{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:45:04Z","timestamp":1777538704129,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, the pathologies of acute meningitis and encephalopathy were investigated, and biomarkers useful as prognostic indices were searched for.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 31 children with meningitis, 30 with encephalopathy, and 12 with convulsions following gastroenteritis. Control group consisted of 24 children with non\u2010central nervous system infection. Cerebrospinal fluid cytokine analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chemokines significantly increased in the bacterial meningitis group compared with those in viral meningitis and encephalopathy groups. On comparison of interleukin(<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017, it increased in cases with status epilepticus in influenza\u2010associated encephalopathy group. In the rotavirus encephalopathy and convulsions following gastroenteritis groups, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 particularly increased in the convulsions following gastroenteritis group. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 increased in all cases irrespective of the causative virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the encephalopathy group, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 may serve as a neurological prognostic index. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 was increased in the convulsions following gastroenteritis group, particularly in cases with status epilepticus, suggesting its involvement as a convulsion\u2010related factor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22162","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T08:42:43Z","timestamp":1489740163000},"source":"Crossref","is-referenced-by-count":13,"title":["Pathological analysis of children with childhood central nervous system infection based on changes in chemokines and interleukin\u201017 family cytokines in cerebrospinal fluid"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-9808","authenticated-orcid":false,"given":"Shinichiro","family":"Morichi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Urabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Medical University  Tokyo 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