{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:17Z","timestamp":1753869377728,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Cystatin C have shown to be a renal function parameter with higher sensitivity and specificity than serum creatinine. In tubular diseases, cystatin C degradation and an increase in its urinary elimination would be observed. We have tried to define if different kinds of kidney diseases may significantly affect the serum levels of cystatin C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Four hundred and four patients were studied: 249 men and 155 women, mean age was 64.3\u00b110.1\u00a0years. Patients were classified into three groups: (1) Chronic interstitial nephropathy (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>), (2) Glomerular nephropathy (<jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>), and (3) Non\u2010 <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients (control). <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was estimated though the <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">EPI<\/jats:styled-content> equation and the Hoek formula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median of serum creatinine levels was higher in <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> group than in <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content> and control groups. Median cystatin C levels were lower in control group compared with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content> groups. No significant differences were found between <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> group and <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content> group. Nevertheless, the cystatin\/creatinine rate was lower in the <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> group patients (0.94, 0.81\u20101.11) than in the <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content> group (1.02,I 0.85\u20101.25) as well as the control group (1.02, I 0.88\u20101.20). The cystatin C\u2010estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>\/creatinine\u2010estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> rate was higher in the <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> group (1.18, 1.03\u20101.36) than in the <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content> patients (1.03, 0.88\u20101.21) and control ones (1.07, 0.88\u20101.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> had lower serum levels of cystatin C defined as cystatin C\/creatinine rate when they were compared with <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content> subject and control ones. In the same way, the index between cystatin C\u2010estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> and creatinine\u2010estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was higher in <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22166","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T17:32:42Z","timestamp":1486747962000},"source":"Crossref","is-referenced-by-count":1,"title":["A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-6691","authenticated-orcid":false,"given":"Nicolas Roberto","family":"Robles","sequence":"first","affiliation":[{"name":"Servicio de Nefrologia. Hospital Infanta Cristina  Badajoz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candido","family":"Mena","sequence":"additional","affiliation":[{"name":"Centro de Salud \u201cJose Mar\u00eda Alvarez\u201d  Don Benito Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Chavez","sequence":"additional","affiliation":[{"name":"Servicio de Nefrologia. Hospital Infanta Cristina  Badajoz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Bayo","sequence":"additional","affiliation":[{"name":"Servicio de Nefrologia. Hospital Infanta Cristina  Badajoz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Gonzalez Candia","sequence":"additional","affiliation":[{"name":"Servicio de Nefrologia. 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