{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:55:27Z","timestamp":1774976127292,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Background<\/jats:title>Studies on homocysteine (Hcy) have mainly focused on the correlation between the homocysteine concentration and disease development. Few epidemiological investigations have been performed. This study was conducted to investigate the prevalence of hyperhomocysteinemia (HH<\/jats:styled-content>cy) during routine physical examination in Guangxi Province, China and the correlation of serum Hcy with gender, age, serum uric acid (UA<\/jats:styled-content>), total cholesterol (TC<\/jats:styled-content>), triglycerides (TG<\/jats:styled-content>), high\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C), low\u2010density lipoprotein cholesterol (LDL<\/jats:styled-content>\u2010C), and blood glucose (GLU<\/jats:styled-content>) to provide evidence for preventing and treating HH<\/jats:styled-content>cy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data of 8043 patients who underwent physical examinations at the First Affiliated Hospital of Guangxi Medical University, China from 2015 to 2016 were collected. These data included gender, age, and the serum Hcy, UA<\/jats:styled-content>, GLU<\/jats:styled-content>, TC<\/jats:styled-content>, TG<\/jats:styled-content>, HDL<\/jats:styled-content>\u2010C, and LDL<\/jats:styled-content>\u2010C concentrations.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall prevalence of HH<\/jats:styled-content>cy was 50.8% (52.3% in males, 48.1% in females). Age, UA<\/jats:styled-content>, TC<\/jats:styled-content>, TG<\/jats:styled-content>, and LDL<\/jats:styled-content>\u2010C were significantly higher and HDL<\/jats:styled-content>\u2010C was significantly lower in patients with than without HH<\/jats:styled-content>cy, regardless of gender (all P<\/jats:italic><.05). The Hcy level was positively correlated with UA<\/jats:styled-content>, TC<\/jats:styled-content>, TG<\/jats:styled-content>, and LDL<\/jats:styled-content>\u2010C but negatively correlated with HDL<\/jats:styled-content>\u2010C. Gender, age, UA<\/jats:styled-content>, TC<\/jats:styled-content>, and TG<\/jats:styled-content> were independent risk factors for HH<\/jats:styled-content>cy.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The prevalence of HH<\/jats:styled-content>cy was very high during routine physical examination in Guangxi Province, China. HH<\/jats:styled-content>cy was related to gender, age, high concentrations of UA<\/jats:styled-content>, TC<\/jats:styled-content>, TG<\/jats:styled-content>, and LDL<\/jats:styled-content>\u2010C; and low concentrations of HDL<\/jats:styled-content>\u2010C. Strengthening early intervention of HH<\/jats:styled-content>cy can reduce the risk of cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22178","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T07:37:46Z","timestamp":1491809866000},"source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of hyperhomocysteinemia during routine physical examination in Guangxi Province, China and related risk factors"],"prefix":"10.1002","volume":"32","author":[{"given":"Yuan\u2010Yuan","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Center The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi Zhuang Autonomous 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