{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:17Z","timestamp":1753869377497,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:00Z","timestamp":1487376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fetuin\u2010A has been described to correlate inversely with vascular calcification both in animal models but also in patients with heart and renal disease. In this current study, we sought to investigate whether fetuin\u2010A might be a useful marker for the discrimination of ischemic (<jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content>) from dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 124 non\u2010consecutive patients were included in this study, 59 patients suffered from <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content> and 65 patients from <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>. Serum samples were obtained during out\u2010patient visits and analyzed for fetuin\u2010A by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median fetuin\u2010A concentration in the overall cohort was significantly lower in <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content> patients compared to <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> patients (62.2\u00b116.4\u00a0\u03bcg\/mL vs. 129.6\u00b156.6\u00a0\u03bcg\/mL; <jats:italic>P<\/jats:italic>&lt;.001). A positive correlation of fetuin\u2010A levels was found with BMI, cholesterol, <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> ratio and triglycerides and an inverse correlation with age (<jats:italic>r<\/jats:italic>=\u2212.36; <jats:italic>P<\/jats:italic>&lt;.001). Moreover, patients suffering from (stable) angina pectoris evidenced lower fetuin\u2010A levels compared to non\u2010symptomatic patients (73.1\u00b122.7\u00a0\u03bcg\/mL vs. 83.7\u00b126.2\u00a0\u03bcg\/mL; <jats:italic>P<\/jats:italic>=.047)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetuin\u2010A was shown to be a potential discriminator and biomarker for the differential diagnosis between <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>. Fetuin\u2010A levels might also be helpful in the process of diagnostic decision\u2010making in regards to invasive management or medical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22179","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T08:42:45Z","timestamp":1487407365000},"source":"Crossref","is-referenced-by-count":11,"title":["Specifics of fetuin\u2010A levels in distinct types of chronic heart failure"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-3931","authenticated-orcid":false,"given":"Michael","family":"Lichtenauer","sequence":"first","affiliation":[{"name":"Department of Cardiology Clinic of Internal Medicine II Paracelsus Medical University of Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Wernly","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinic of Internal Medicine II Paracelsus Medical 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