{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:41:21Z","timestamp":1775792481916,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to verify the influence of oral contraceptives (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>s) on lipid profile and the arylesterase, lactonase and phosphotriesterase activities of paraoxonase 1 (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1). Also commonly hepatic enzymes: aspartate aminotransferase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>), alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) and \u03b3\u2010glutamyltranspherase (<jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content>) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lipid profile and hepatic enzymes were determined using commercial available reagents. Paraoxonase activities were estimated using earlier published procedures. Blood samples were collected from 120 women of similar age (22.6\u00b11.0\u00a0years) with similar <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (20.71\u00b12.20\u00a0kg\/m<jats:sup>2<\/jats:sup>). Participations were divided into two groups: 74 females do not take (group A) and 46 women taking <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>s (group B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher triglycerides and lower low\u2010density lipoproteins levels were observed in group B than in group A) (56.9\u00b119.7\u00a0mg\/dL. Castelli risk index I was significantly higher in group B when compared to group A (<jats:italic>P<\/jats:italic>&lt;.0001), whereas we did not observe any statistically significant differences in Castelli risk index II value between studied groups. In group B, increase in <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> activities were found, while the de Ritis ratio was lower in group B than in group A.<\/jats:p><jats:p>In group B, lower phosphotriesterase activity and higher arylesterase and lactonase activities were found when compared to group A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> activities in serum as well as changes in lipid profile and <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content> activities can indicate that <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>s usage can cause disorder in these parameters in the serum of women taking <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22194","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T11:05:28Z","timestamp":1489057528000},"source":"Crossref","is-referenced-by-count":18,"title":["Influence of oral contraceptives on lipid profile and paraoxonase and commonly hepatic enzymes activities"],"prefix":"10.1002","volume":"32","author":[{"given":"Katarzyna","family":"Kowalska","sequence":"first","affiliation":[{"name":"Department of Biomedical and Environmental Analyses Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"\u015aciskalska","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Environmental Analyses Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-6878","authenticated-orcid":false,"given":"Anna","family":"Bizo\u0144","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Environmental Analyses Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariola","family":"\u015aliwi\u0144ska\u2010Mosso\u0144","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Environmental Analyses Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halina","family":"Milnerowicz","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Environmental Analyses Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767120-00007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-7802.104862"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.09.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(97)00023-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149122"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S59852"},{"key":"e_1_2_6_8_1","first-page":"245","article-title":"Comparison of postprandial lipemia between women who are on oral contraceptive methods and those who are not","volume":"103","author":"Petto J","year":"2014","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1048"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","DOI":"10.4314\/ahs.v12i2.6","article-title":"Association of paraoxonase activity and atherosclerosis in patients with chronic hepatitis B","volume":"12","author":"Karsen H","year":"2012","journal-title":"Afr Health Sci"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756360802608351"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581815584624"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2015.1089533"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.01.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.681653"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.7.1209"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-013-0392-2"},{"key":"e_1_2_6_18_1","first-page":"1126","article-title":"The human serum paraoxonase\/arylesterase polymorphism","volume":"35","author":"Eckerson HW","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000298879"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.00889.x"},{"key":"e_1_2_6_21_1","first-page":"315","article-title":"Pharmacodynamics of combined estrogen\u2010progestin oral contraceptives: 1. Effects on metabolism","volume":"10","author":"Bastianelli C","year":"2017","journal-title":"Expert Rev Clin Pharmacol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535953"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.11.021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13531-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/818570"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90408-1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60518-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00018-3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(00)00174-4"},{"key":"e_1_2_6_30_1","first-page":"1379","article-title":"Effect of hormonal contraceptives on serum lipids: a prospective study","volume":"29","author":"Dilshad H","year":"2016","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1062860"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2003.11.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701325731"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(00)00083-4"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.12.005"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-016-0064-x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.6.1816"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.02.033"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045162"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.02.015"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119134"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.05.001"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.09.120"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00272-X"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400511-JLR200"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.01.020"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:07:22Z","timestamp":1694941642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jcla.22194"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22194","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,9]]},"article-number":"e22194"}}