{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:20:08Z","timestamp":1777645208903,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Background<\/jats:title>Carpal tunnel syndrome (CTS<\/jats:styled-content>) is a common neurologic impairment caused by injury on the median nerve in the wrist, characterized by pain and loss of sensory. CTS<\/jats:styled-content> usually occurs through three factors, such as a mechanical pressure on median nerve, immunologic changes, and oxidative stress. The aim of this study was to evaluate the influence of interleukin\u20101 receptor antagonist (IL<\/jats:styled-content>\u20101Ra<\/jats:italic>) and angiotensin\u2010converting enzyme (ACE<\/jats:styled-content><\/jats:italic>) I\/D polymorphisms on the susceptibility of patients to the CTS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred fifty\u2010eight patients with CTS<\/jats:styled-content> and 151 healthy controls were enrolled in this study. Each patient was analyzed according to diseases symptoms, such as gender, a positive Tinel's sign, a positive Phalen maneuver, disease sides, EMG<\/jats:styled-content> findings, and clinical stage. We applied the polymerase chain reaction (PCR<\/jats:styled-content>) to determine the polymorphisms of IL<\/jats:styled-content>\u20101Ra<\/jats:italic> and ACE<\/jats:styled-content><\/jats:italic> I\/D.<\/jats:p><\/jats:sec>Results<\/jats:title>The statistically significant relation was not found between IL<\/jats:styled-content>\u20101Ra, ACE<\/jats:styled-content><\/jats:italic> I\/D polymorphisms and CTS<\/jats:styled-content> (respectively, P<\/jats:italic>>.05; P<\/jats:italic>>.05, OR<\/jats:styled-content>: 1.51, CI<\/jats:styled-content>: 0.82\u20101.61). Additionally, in the result of the statistical analysis compared with gene polymorphisms and clinical characteristics, we did not find any correlation (P<\/jats:italic>>.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings showed that there are no associations of IL<\/jats:styled-content>\u20101Ra<\/jats:italic> and ACE<\/jats:styled-content><\/jats:italic> I\/D polymorphisms with susceptibility of a person for the development of CTS<\/jats:styled-content>. So, it means that these polymorphisms do not create a risk for the development of CTS<\/jats:styled-content>. Further studies with larger populations will be required to confirm these findings in different study populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22204","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T12:55:50Z","timestamp":1490792150000},"source":"Crossref","is-referenced-by-count":4,"title":["The investigation of association between IL\u20101Ra<\/i> and ACE<\/i> I\/D polymorphisms in carpal tunnel syndrome"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-6589","authenticated-orcid":false,"given":"Betul","family":"Cevik","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Neurology Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-6657","authenticated-orcid":false,"given":"Akin","family":"Tekcan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Biology Ahi Evran University Kirsehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Inanir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Physical Medicine and Rehabilitation Gaziosmanpasa University Tokat Turkey"},{"name":"Academic Pain\u2010Hernia Center Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semiha Gulsum","family":"Kurt","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Neurology Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-3964","authenticated-orcid":false,"given":"Serbulent","family":"Yigit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Biology Gaziosmanpasa University Tokat 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