{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:30:49Z","timestamp":1769549449335,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Purpose<\/jats:title>Chronic Helicobacter pylori<\/jats:italic> gastritis affects two\u2010thirds of the world's population and is one of the most common chronic inflammatory disorders of humans, the infection clearly results in chronic mucosal inflammation in the stomach and duodenum, which, in turn, might lead to abnormalities in gastroduodenal motility and sensitivity and is the most frequent cause of dyspepsia and peptic disease. Some studies showed that there was a correlation between low\u2010grade inflammation as CRP<\/jats:styled-content> and HP<\/jats:styled-content> infection. The purpose of this study was to investigate the relationship between the presence of HP<\/jats:styled-content> infection and platelet\/lymphocyte ratio (PLR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Method<\/jats:title>A total of 200 patients who met the HP<\/jats:styled-content> criteria and 180 age\u2010 and gender\u2010matched control subjects were included in this randomized controlled trial. Patients were diagnosed to have HP<\/jats:styled-content> according stomach biopsy and urea breath test, PLR<\/jats:styled-content> was calculated from complete blood count at time of diagnosis and before initiating the treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with HP<\/jats:styled-content> infection had significantly higher PLR<\/jats:styled-content> compared to those without HP<\/jats:styled-content>. Moreover, the patients with symptomatic HP<\/jats:styled-content> had higher PLR<\/jats:styled-content> than those with asymptomatic HP<\/jats:styled-content>. While PLR<\/jats:styled-content> increased as the severity of HP<\/jats:styled-content> symptoms increased (r<\/jats:italic>=.452, P<\/jats:italic><.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study indicated, for the first time, a significant association between HP<\/jats:styled-content> infection and symptoms based on PLR<\/jats:styled-content>, a simple and reliable indicator of inflammation. Furthermore, there an increase in PLR<\/jats:styled-content> as the severity of HP<\/jats:styled-content> increases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22222","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:28:14Z","timestamp":1491409694000},"source":"Crossref","is-referenced-by-count":18,"title":["A link between platelet to lymphocyte ratio and Helicobacter pylori<\/i> infection"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9777-5106","authenticated-orcid":false,"given":"Raymond","family":"Farah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B Ziv Medical Center Safed Israel"},{"name":"Faculty of Medicine in the Galilee Bar\u2010Ilan University Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Hamza","sequence":"additional","affiliation":[{"name":"Nephrology Unit Ziv Medical Center Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rola","family":"Khamisy\u2010farah","sequence":"additional","affiliation":[{"name":"Clalit Health Service Akko Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)80224-5"},{"issue":"2","key":"e_1_2_7_3_1","first-page":"33","article-title":"The prevalence of Helicobacter pylori infection in different countries","volume":"9","author":"Pounder RE","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05562"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"85","article-title":"Transmission of Helicobacter pylori: faecal\u2010oral versus oral\u2010oral route","volume":"9","author":"M\u00e9graud F","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1211.060086"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.272.1.65"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00380-008-1062-9","article-title":"High immunoglobulin A seropositivity for combined Chlamydia pneumoniae, Helicobacter pylori infection, and high\u2010sensitivity C\u2010reactive protein in coronary artery disease patients in India can serve as atherosclerotic marker","volume":"23","author":"Jha HC","year":"2008","journal-title":"Heart Vessels"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.054"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442939"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21669"},{"key":"e_1_2_7_14_1","unstructured":"Centers for Disease Control and Prevention (CDC).Helicobacter pylori.http:\/\/www.cdc.gov\/ncidod\/aip\/research\/hp.html. 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