{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:02:56Z","timestamp":1773046976548,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Background<\/jats:title>The non\u2010invasive diagnostic approach for early detection of endometrial cancer (EC<\/jats:styled-content>) remains limited. To date, human epididymis protein 4 (HE<\/jats:styled-content>4) has been intensively studied but its diagnostic is controversial inEC<\/jats:styled-content>.DJ<\/jats:styled-content>\u20101 is an oncoprotein secreted by cancer cells, recently identified as a potential diagnostic biomarker for breast cancer, melanoma, and pancreatic cancer. The aim of this study was to compare the diagnostic performances ofDJ<\/jats:styled-content>\u20101 andHE<\/jats:styled-content>4 measured inEC<\/jats:styled-content>patients and healthy controls (HC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010five patients (63.9\u00b112.0\u00a0years) withEC<\/jats:styled-content>and 29 (63.2\u00b113.3\u00a0years)HC<\/jats:styled-content>were enrolled. Serum concentrations ofDJ<\/jats:styled-content>\u20101 andHE<\/jats:styled-content>4 were measured usingELISA<\/jats:styled-content>kits developed by R&D (Minneapolis,USA<\/jats:styled-content>) and Fujirebio Diagnostic (Malvern,PA<\/jats:styled-content>,USA<\/jats:styled-content>), respectively. Differences betweenEC<\/jats:styled-content>patients andHC<\/jats:styled-content>were assessed by Mann\u2010Whitney test and associations were tested by Spearman's correlation. The diagnostic performance was assessed using receiver operating characteristics (ROC<\/jats:styled-content>) curves analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>SerumDJ<\/jats:styled-content>\u20101 concentrations were found to be higher inEC<\/jats:styled-content>patients than inHC<\/jats:styled-content>(9533.6 vs 1988.5\u00a0pg\/mL;P<\/jats:italic><.0001). The area under theROC<\/jats:styled-content>curve (ROC<\/jats:styled-content>\u2010AUC<\/jats:styled-content>) was 0.95 (P<\/jats:italic><.0001). At the cut\u2010off of 3654\u00a0pg\/mL, the sensitivity and specificity were 0.89 and 0.90, respectively.HE<\/jats:styled-content>4 serum levels were higher inEC<\/jats:styled-content>patients than inHC<\/jats:styled-content>(75.3 vs 56.2\u00a0pmol\/L;P<\/jats:italic>=.019), with anAUC<\/jats:styled-content>of 0.66 (P<\/jats:italic>=.020). TheAUC<\/jats:styled-content>obtained by the combination of the two markers resulted 0.96 (P<\/jats:italic><.0001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These results suggest that increased serumDJ<\/jats:styled-content>\u20101 levels are associated withEC<\/jats:styled-content>and that this biomarker may be potentially useful for diagnosingEC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22223","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:27:49Z","timestamp":1491409669000},"source":"Crossref","is-referenced-by-count":20,"title":["The clinical significance ofDJ<\/scp>\u20101 andHE<\/scp>4 in patients with endometrial cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"Marco","family":"Benati","sequence":"first","affiliation":[{"name":"Department of Neurological, Biomedical and Movement Sciences Clinical Biochemistry Section University of Verona Verona 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