{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:53:31Z","timestamp":1790146411615,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Background<\/jats:title>Rapid influenza diagnostic tests (RIDT<\/jats:styled-content>s) show variable sensitivities in clinical settings. We aimed to compare three digital RIDT<\/jats:styled-content>s and one conventional RIDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We assessed 218 nasopharyngeal swabs from patients between neonates and 90\u00a0years old in 2016. Three digital RIDT<\/jats:styled-content>s were BUDDI<\/jats:styled-content>, Sofia Influenza A+B Fluorescence Immunoassay, Veritor System Flu A+B assay. One conventional test was the SD Bioline Influenza Ag A\/B\/A(H1N1\/2009). All test results were compared with those from the Anyplex Flu A\/B Typing Real\u2010time Detection real\u2010time PCR<\/jats:styled-content>. The four RIDT<\/jats:styled-content>s were tested with diluted solutions from the National Institute for Biological Standards and Control (NIBSC<\/jats:styled-content>) to compare lower detection limit. Cross\u2010reactivity of four RIDT<\/jats:styled-content>s within other respiratory viruses was identified.<\/jats:p><\/jats:sec>Results<\/jats:title>For influenza A, BUDDI<\/jats:styled-content>, Sofia, Veritor, and Bioline showed 87.7%, 94.5%, 87.7%, and 72.6% sensitivity, and 100%, 97.7%, 96.5%, and 100% specificity. For influenza B, BUDDI<\/jats:styled-content>, Sofia, Veritor, and Bioline showed 81.7%, 91.7%, 81.7%, and 78.3% sensitivity, and 100%, 95.3%, 100%, and 100% specificity, respectively. Each RIDT<\/jats:styled-content> could detect diluted NIBSC<\/jats:styled-content> solution, according to the level of dilution and specific influenza subtypes. Cross\u2010reactivity of four RIDT<\/jats:styled-content>s with other respiratory viruses was not noted.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Sofia showed the highest sensitivity for influenza A and B detection. BUDDI<\/jats:styled-content> and Veritor showed higher detection sensitivity than a conventional RIDT<\/jats:styled-content> for influenza A detection, but similar results for influenza B detection. Further study is needed to compare the test performance of RIDT<\/jats:styled-content>s according to specific, prevalent influenza subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22234","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:25:57Z","timestamp":1492107957000},"source":"Crossref","is-referenced-by-count":16,"title":["Comparison of three rapid influenza diagnostic tests with digital readout systems and one conventional rapid influenza diagnostic test"],"prefix":"10.1002","volume":"32","author":[{"given":"Sook Won","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Kangwon National University School of Medicine Chuncheon Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Bum","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Kangwon National University School of Medicine Chuncheon Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u2010Min","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kangwon National University School of Medicine Chuncheon Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Sung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Hallym University College of Medicine Chuncheon Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon\u2010Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University Wonju College of Medicine Wonju Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Uh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University Wonju College of Medicine Wonju Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kap Jun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University Wonju College of Medicine Wonju Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-8443","authenticated-orcid":false,"given":"Jong\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University Wonju College of Medicine Wonju Gangwon\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05016-11"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3060"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/598513"},{"key":"e_1_2_6_5_1","unstructured":"World Health Organization (WHO). int [http:\/\/www.who.int\/en\/].Geneva: Use of influenza rapid diagnostic tests.2010.http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241599283_eng.pdf. 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