{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:21Z","timestamp":1753869381308,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Definition of Cardiac Syndrome X (<jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content>) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content> is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> gene cause inactivation of the <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content>, with C677T polymorphism on <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> gene based on genetic basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 176 <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content> patients and 196 healthy subjects with similar age and clinical features were compared in terms of C677T polymorphism of the <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>There was no significant difference in terms of <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> gene C677T polymorphism between <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content> patients and controls. When genotypic distribution was compared based on gender in both patients and controls, no significant difference was found between male and female subjects (<jats:italic>P<\/jats:italic>&gt;.05). As fasting blood sugar and urea values were significantly higher, alanine aminotransferase and gamma\u2010glutamyl transferase levels were significantly lower in the patients than the controls (<jats:italic>P<\/jats:italic>&lt;.05). Described family story of the patients was significantly higher than the controls (<jats:italic>P<\/jats:italic>&lt;.05). These suggest that homocysteine metabolism in <jats:styled-content style=\"fixed-case\">CSX<\/jats:styled-content> is not directly related to the endothelial dysfunction and thus the effect on the microvascular circulation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22247","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T12:36:45Z","timestamp":1494247005000},"source":"Crossref","is-referenced-by-count":1,"title":["Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients"],"prefix":"10.1002","volume":"32","author":[{"given":"Cemre","family":"Kandaz","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology Cerrahpasa Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-0889","authenticated-orcid":false,"given":"Burak","family":"\u00d6nal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology Faculty of Medicine Istinye University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"\u00d6zen","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Cerrahpasa Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bakirkoy Dr. Sadi Konuk Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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