{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:35:13Z","timestamp":1761863713782,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Background<\/jats:title>Temporomandibular joint disorders (TMD<\/jats:styled-content>) are a group of disorders involving temporomandibular joint and related structures. Interleukine\u20101 receptor antagonist (IL<\/jats:styled-content>\u20101Ra) is an important anti\u2010inflammatory molecule that competes with other interleukin\u20101 molecules. This study was designed to investigate the possible association of the IL<\/jats:styled-content>\u20101Ra <\/jats:italic>VNTR<\/jats:styled-content> variant with the risk of TMD<\/jats:styled-content> in the Turkish population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Peripheral blood samples were collected from 100 patients with TMD<\/jats:styled-content> (23 males, 77 females) and 110 healthy individuals (35 males, 75 females). Genotyping of IL<\/jats:styled-content>\u20101Ra<\/jats:italic> 86\u00a0bp VNTR<\/jats:styled-content> variant was evaluated by gel electrophoresis after polymerase chain reaction (PCR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Our results show that there is a statistically significant difference between TMD<\/jats:styled-content> patients and control group with respect to IL<\/jats:styled-content>\u20101Ra genotype distribution and allele frequencies. 1.2, 1.4, and 4.4 genotypes were more common in patients, while 2.2 and 3.3 genotypes were rarer (P<\/jats:italic><.000). Frequency of alleles 1 and 4 was higher in patient groups (P<\/jats:italic><.000), whereas alleles 2 and 3 had a lower frequency in patients with TMD<\/jats:styled-content> (P<\/jats:italic><.000).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This is the first correlation study that evaluates the association between IL<\/jats:styled-content>\u20101Ra<\/jats:italic> gene VNTR<\/jats:styled-content> variant and TMD<\/jats:styled-content>. The VNTR<\/jats:styled-content> variant related to IL<\/jats:styled-content>\u20101Ra<\/jats:italic> gene showed a strong pattern of association with TMD<\/jats:styled-content> that may have a potential impact on disease counseling and management. Larger studies with various ethnicities are needed to establish the impact of IL<\/jats:styled-content>\u20101Ra <\/jats:italic>VNTR<\/jats:styled-content> variant on risk of developing TMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22255","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T12:06:44Z","timestamp":1497442004000},"source":"Crossref","is-referenced-by-count":6,"title":["The IL\u20101Ra<\/i> gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population"],"prefix":"10.1002","volume":"32","author":[{"given":"Mehmet Kemal","family":"Tumer","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Department of Oral and Maxillofacial Surgery Gaziosmanpasa University Tokat Turkey"},{"name":"Faculty of Medicine Department of Medical Biology Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse 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