{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:07:52Z","timestamp":1784167672323,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572069"],"award-info":[{"award-number":["81572069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Objectives<\/jats:title>T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> is a promising diagnosis tool to identify both pulmonary tuberculosis and extrapulmonary tuberculosis, as well as latent tuberculosis; however, the factors that affect the results of T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> remains unclear. In this study, we aim to figure out the risk factor of T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> for active TB<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 349 patients were recruited between January 1st, 2016 and January 22st, 2017 at Renmin Hospital of Wuhan University, including 98 subjects with TB<\/jats:styled-content> and 251 subjects with non\u2010TB<\/jats:styled-content> disease, and received T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> (Oxford Immunotec Ltd). Statistics were analyzed by SPSS<\/jats:styled-content> 19.0 using logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>The overall specificity and sensitivity of the T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> was 92.83% (233\/251; 95%CI<\/jats:styled-content> 0.8872\u20100.9557) and 83.67% (82\/98; 95%CI<\/jats:styled-content> 0.7454\u20100.9010), respectively. Patients with tuberculous meningitis were more likely to have false\u2010negative results (OR<\/jats:styled-content> 17.4, 95%CI<\/jats:styled-content> 3.068\u201098.671; P<\/jats:italic><.001) while patients with cured TB<\/jats:styled-content> tended to induce false\u2010positive results (OR<\/jats:styled-content> 30.297; 95%CI<\/jats:styled-content> 7.069\u2010129.849; P<\/jats:italic><.001). The results were not affected by sex, age, onset time, smoke, alcohol, treatment, allergic history, co\u2010morbidity, TB<\/jats:styled-content> (exclude tuberculous meningitis) (P<\/jats:italic>>.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Tuberculous meningitis was a risk factor of false\u2010negative for T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content>, while cured TB<\/jats:styled-content> was a risk factor of false\u2010positive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22273","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T11:22:58Z","timestamp":1496920978000},"source":"Crossref","is-referenced-by-count":29,"title":["The risk factor of false\u2010negative and false\u2010positive for T\u2010SPOT<\/scp>.TB<\/scp> in active tuberculosis"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-7751","authenticated-orcid":false,"given":"Li","family":"Di","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2014(WHO 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