{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:32:33Z","timestamp":1779337953720,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Rapid and practical point\u2010of\u2010care testing (POCT) devices become more popular, especially in blood donation centers for determining predonation hemoglobin (Hb) concentrations. The purpose of this study was to evaluate accordance between the POCT methods and the venous method as the reference to Hb screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 353 subjects with no known significant health problems were included in the study. Hb screening was performed by two different POCT methods, a noninvasive method (Haemospect, MBR, Germany) and an invasive method (HemoControl, EKF Diagnostic, Germany), and a venous method as the reference (Sysmex XE\u20102100, Sysmex Europe, Germany). The obtained results were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sensitivity and the specificity values of the invasive POCT method (83.3%, 87.9%) were higher than the noninvasive POCT method (66.7%, 77.1%). The Bland\u2010Altman analysis was evaluated for both sexes and the bias of the noninvasive POCT method of the males (\u22120.97\u00a0g\/dL) was higher than the bias of the invasive POCT method of the males (\u22120.07\u00a0g\/dL). We found a better correlation between the invasive POCT method (<jats:italic>r\u00a0<\/jats:italic>=\u00a0.908) compared with the venous method than the noninvasive POCT method (<jats:italic>r\u00a0<\/jats:italic>=\u00a0.634).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Predonation Hb measurements must be performed with accurate, precise, and practical methods. Although the noninvasive POCT method was practical and painless, it had lower levels of specificity and sensitivity, and more false deferral and pass rates than the invasive POCT method. The POCT methods agreeable to the venous method as the reference might be suitable for Hb screening especially for centers of excessive numbers of blood donation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22309","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T12:42:44Z","timestamp":1503492164000},"source":"Crossref","is-referenced-by-count":15,"title":["Comparison of noninvasive and invasive point\u2010of\u2010care testing methods with reference method for hemoglobin measurement"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-2641","authenticated-orcid":false,"given":"Gamze","family":"Avcioglu","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine  Ankara Turkey"},{"name":"Department of Clinical Biochemistry Ankara Atat\u00fcrk Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemil","family":"Nural","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine  Ankara Turkey"},{"name":"Department of Clinical Biochemistry Ankara Atat\u00fcrk Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Meri\u00e7","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine  Ankara Turkey"},{"name":"Department of Clinical Biochemistry Ankara Atat\u00fcrk Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pervin","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Ankara Atat\u00fcrk Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine  Ankara Turkey"},{"name":"Department of Clinical Biochemistry Ankara Atat\u00fcrk Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclsen","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine  Ankara Turkey"},{"name":"Department of Clinical Biochemistry Ankara Atat\u00fcrk Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Medicines EDftQo.Guide to the preparation use and quality assurance of blood components. Recommendation No R (95) 152013."},{"key":"e_1_2_6_3_1","unstructured":"Food U. Drug Administration.Title 21 Code of Federal Regulation.www.gpo.gov\/fdsys\/pkg\/CFR-2010-title21-vol7\/pdf\/CFR-2010-title21-vol7-sec640-3.pdf. Accessed December 12 2016."},{"key":"e_1_2_6_4_1","unstructured":"European Directorate for the Quality of Medicines and Health Care (EDQM) 2016.http:\/\/www.edqm.eu\/en\/Good-practiceguidelines-for-blood-establishments-1587.html?mbID=155. Accessed December 15 2016."},{"key":"e_1_2_6_5_1","unstructured":"T\u00fcrk K\u0131z\u0131lay\u0131 Kan Hizmetleri Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc.2015."},{"key":"e_1_2_6_6_1","unstructured":"Bakanl\u0131\u011f\u0131 TS.Ulusal kan ve kan \u00fcr\u00fcnleri rehberi. T\u00fcrkiye Kan Merkezleri ve Transf\u00fczyon Derne\u011fi \u0130stanbul.2011."},{"key":"e_1_2_6_7_1","first-page":"191","article-title":"Validity and correspondence of non\u2010invasively determined hemoglobin concentrations by two trans\u2010cutaneous digital measuring devices","volume":"21","author":"Crowley C","year":"2012","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_6_8_1","unstructured":"MBR Optical Systems Haemospect.https:\/\/www.mbr-optical-systems.com\/download\/flyer-haemospect-en.pdf. Accessed December 10 2016."},{"key":"e_1_2_6_9_1","unstructured":"EKF Diagnostics HemoControl.http:\/\/www.ekfdiagnostics.com\/res\/Hemo%20Control%20Presentation.pdf. Accessed December 10 2016."},{"key":"e_1_2_6_10_1","unstructured":"Sysmex XE\u20102100 Brochure.https:\/\/www.cmmc.org\/cmmclab\/IFU\/XE-2100.PDF. 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