{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:07:41Z","timestamp":1785208061152,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601423"],"award-info":[{"award-number":["81601423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600399"],"award-info":[{"award-number":["81600399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Biliary atresia (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) is a neonatal disease characterized by chronic inflammation of the bile ducts and progressive aggravation of jaundice, but with a poor prognosis and high mortality. The etiology of <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> is still uncertain which may be related to gene defect, virus infection, immune disorder, gene polymorphism. As a proinflammatory cytokine, <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> gene polymorphism (rs3025039) has been shown to be related to the pathogenesis of <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> in Taiwanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the association between <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> gene polymorphism (rs3025039) and <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> susceptibility using the largest case\u2010control cohort, totaling with 506 <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> patients and 1473 healthy controls in a Southern Chinese Han population. <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> gene polymorphism (rs3025039) was genotyped using the Mass<jats:styled-content style=\"fixed-case\">ARRAY iPLEX<\/jats:styled-content> Gold system (Sequenom). Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were used to access the association between the <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> gene polymorphism (rs3025039) and <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant association was found between the <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> gene polymorphism (rs3025039) and <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> risk in the overall analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> gene polymorphism (rs3025039) may not be associated with the risk of <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> in the Southern Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22342","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T11:29:25Z","timestamp":1513596565000},"source":"Crossref","is-referenced-by-count":13,"title":["Association of polymorphism in the <scp>VEGFA<\/scp> gene 3\u2032\u2010<scp>UTR<\/scp> +936T\/C with susceptibility to biliary atresia in a Southern Chinese Han population"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-3066","authenticated-orcid":false,"given":"Fei","family":"Liu","sequence":"first","affiliation":[{"name":"Southern Medical University  Guangzhou Guangdong"},{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Southern Medical University  Guangzhou Guangdong"},{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Feng","sequence":"additional","affiliation":[{"name":"Southern Medical University  Guangzhou Guangdong"},{"name":"Division of Neonatology Affiliated BaYi Children's Hospital Clinical Medical College in PLAArmy General Hospital Southern Medical University  Beijing China"},{"name":"National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology  Beijing China"},{"name":"Beijing Key Laboratory of Pediatric Organ Failure  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2016.04.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2014.01.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1681-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.022"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.03.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.04.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.032"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2809"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1280-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.07.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.20"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138381"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i8.1167"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b152c2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2016.02.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.12.058"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12900"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(00)90211-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.038"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.047"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.030"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.01.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.09.003"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:17:32Z","timestamp":1695471452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/jcla.22342"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22342","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]},"article-number":"e22342"}}