{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:12:34Z","timestamp":1790723554213,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Among the fungal pathogens, <jats:italic>Candida<\/jats:italic> species are the most common cause of urinary tract infection (<jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>). Some predisposing factors such as diabetes mellitus, urinary retention, urinary stasis, renal transplantation, and hospitalization can increase the risk of candiduria. The aim of this cross\u2010sectional study was to evaluate candiduria among type 2 diabetic patients and identification of the <jats:italic>Candida<\/jats:italic> isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Four hundred clean\u2010catch midstream urine specimens were obtained from patients with type 2 diabetes mellitus. The specimens were centrifuged and the sediments were examined by direct examination and cultured on Sabouraud dextrose agar. The plates were incubated for 2\u20103\u00a0days at 35\u00b0C. The <jats:italic>Candida<\/jats:italic> colonies were counted and purified using <jats:styled-content style=\"fixed-case\">CHROM<\/jats:styled-content>agar <jats:italic>Candida<\/jats:italic>. The isolates were identified by matrix\u2010assisted laser desorption ionization\u2010time of flight mass spectrometry (<jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF MS<\/jats:styled-content>) system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 400 urine specimens, 40 (10%) had positive cultures for <jats:italic>Candida<\/jats:italic> species with a colony count of \u22651\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup> colony forming units (<jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>)\/mL. The frequencies of the <jats:italic>Candida<\/jats:italic> species were as follows: <jats:italic>C.\u00a0albicans (<\/jats:italic>n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>19, 47.5%), <jats:italic>C.\u00a0glabrata<\/jats:italic> (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>15, 37.5%), <jats:italic>C.\u00a0kefyer<\/jats:italic> (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4, 10%) and <jats:italic>C.\u00a0krusei<\/jats:italic> (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2, 5%). Seventy<jats:italic>\u2010<\/jats:italic>three (88%) of the patients with candiduria had hemoglobin A1c (HbA1c) levels above 7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of candiduria was relatively high in type 2 diabetic patients and they were also suffering from a lack of proper blood glucose control. Although the frequency of non\u2010<jats:italic>albicans Candida<\/jats:italic> species had not significantly higher than <jats:italic>C.\u00a0albicans<\/jats:italic>, however, they obtained more from those with symptomatic candiduria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22343","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T10:47:44Z","timestamp":1509101264000},"source":"Crossref","is-referenced-by-count":42,"title":["High prevalence of candiduria due to non\u2010<i>albicans Candida<\/i> species among diabetic patients: A matter of concern?"],"prefix":"10.1002","volume":"32","author":[{"given":"Alireza","family":"Esmailzadeh","sequence":"first","affiliation":[{"name":"Department of Parasitology and Mycology School of Medicine Mashhad University of Medical Sciences  Mashhad 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