{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:59Z","timestamp":1786978019211,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Therapeutic monitoring of tacrolimus is essential for reducing organ rejection and adverse\n                      <jats:italic>\u00a0<\/jats:italic>\n                      effects. The measurement of tacrolimus in whole blood is taken by many automated platforms. We evaluated the analytical performance of the Dimension\n                      <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                      assay, which is an upgraded reagent from the previous Dimension\n                      <jats:styled-content style=\"fixed-case\">TACR<\/jats:styled-content>\n                      assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The evaluations involved determination of precision, linearity, detection capability, and reagent lot\u2010to\u2010lot variability between three lot numbers. Correlation studies were conducted using the Dimension\n                      <jats:styled-content style=\"fixed-case\">TACR<\/jats:styled-content>\n                      assay, Architect, Elecsys assay, and MassTrak\n                      <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total coefficient of variation was below 10%. Acceptable linearity was observed in their respective reportable ranges. The limit of blank, limit of detection, and limit of quantification were 0.29, 0.47, and 0.81\u00a0ng\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      , respectively. Correlation analysis indicated that the Dimension\n                      <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                      assay results were comparable to that of the Dimension\n                      <jats:styled-content style=\"fixed-case\">TACR<\/jats:styled-content>\n                      assay, Architect, and Elecsys results in liver and heart transplant patients. In kidney transplant patients, the Dimension\n                      <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                      assay showed the poor correlation with Architect and Elecsys. The results from these assays were slightly higher than that of MassTrak. We found little lot\u2010to\u2010lot reagent variation among the reagents evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The overall analytical performance of the Dimension\n                      <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>\n                      assay is acceptable for therapeutic monitoring in clinical practice. Our study that compared different platforms may provide some useful information regarding which test method to use.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.22357","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T04:18:38Z","timestamp":1510892318000},"source":"Crossref","is-referenced-by-count":10,"title":["Performance of the Dimension\n                    <scp>TAC<\/scp>\n                    assay and comparison of multiple platforms for the measurement of tacrolimus"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-9639","authenticated-orcid":false,"given":"Eun\u2010Jung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The Catholic University of Korea College of Medicine Uijeongbu St. Mary's Hospital  Uijeongbu Korea"},{"name":"Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Hallym University College of Medicine Dongtan Sacred Heart Hospital  Hwaseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woochang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sail","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae\u2010Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Catholic University of Korea College of Medicine Uijeongbu St. Mary's Hospital  Uijeongbu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3163"},{"key":"e_1_2_5_3_1","first-page":"485","article-title":"A review on therapeutic drug monitoring of immunosuppressant drugs","volume":"14","author":"Mohammadpour N","year":"2011","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00911.x"},{"issue":"1","key":"e_1_2_5_5_1","first-page":"940","article-title":"Measurement of FK 506 by HPLC and isolation and characterization of its metabolites","volume":"23","author":"Christians U","year":"1991","journal-title":"Transpl Proc"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(99)80044-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200211000-00014"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00249"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.9.1905"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010429"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13309"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.778"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.220012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(98)00086-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.06.012"},{"key":"e_1_2_5_16_1","first-page":"61","article-title":"Review of the newest HPLC methods with mass spectrometry detection for determination of immunosuppressive drugs in clinical practice","volume":"14","author":"Korecka M","year":"2009","journal-title":"Ann Transplant"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2008.05.001"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31819c6a37"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.05.079"},{"key":"e_1_2_5_20_1","unstructured":"Dimension\u00aeTAC method [package insert].NY USA:Siemens Healthcare Diagnostics;2014."},{"key":"e_1_2_5_21_1","volume-title":"Urinalysis; Approved Guideline. 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