{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:31Z","timestamp":1753869391132,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000241","name":"Physicians' Services Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Background<\/jats:title>A decrease in serum low\u2010density lipoprotein cholesterol (LDL<\/jats:styled-content>\u2010C) is well documented after acute stress. Plasma proprotein convertase subtilisin kexin 9 (PCSK<\/jats:styled-content>9), which promotes degradation of low\u2010density lipoprotein receptor (LDL<\/jats:styled-content>\u2010R) resulting in reduced plasma clearance of low\u2010density lipoproteins (LDL<\/jats:styled-content>) and an increase in serum LDL<\/jats:styled-content>\u2010C, would be predicted to decrease. Yet, a few studies have demonstrated an increase 1\u20108\u00a0days after acute stress. Our objective was to assess the earlier status of plasma PCSK<\/jats:styled-content>9, within the first 24\u00a0hours of onset of stress.<\/jats:p><\/jats:sec>Methods<\/jats:title>We measured serum lipids and plasma PCSK<\/jats:styled-content>9 in 39 patients before and soon after an elective surgical procedure (abdominal aortic aneurysm (AAA<\/jats:styled-content>) repair).<\/jats:p><\/jats:sec>Results<\/jats:title>We observed an early decrease in PCSK<\/jats:styled-content>9 following surgery, as well as a decrease in total cholesterol (TC<\/jats:styled-content>), LDL<\/jats:styled-content>\u2010C, high\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C), non\u2013high\u2010density lipoprotein cholesterol (non\u2010HDL<\/jats:styled-content>\u2010C) and triglycerides (TG<\/jats:styled-content>).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Unlike other studies which showed an increase in PCSK<\/jats:styled-content>9 after the onset of stress, our study detected a fall in PCSK<\/jats:styled-content>9 following acute surgical stress. The observed difference is likely due to the earlier timing of PCSK<\/jats:styled-content>9 measurement in our study. Further studies involving serial poststress measurements for several days are needed to determine whether PCSK<\/jats:styled-content>9 behaves as an acute\u2010phase reactant, whether it displays a biphasic response to acute stress, and whether changes in circulating PCSK<\/jats:styled-content>9 are responsible for lipoprotein changes observed after surgical stress. (Clinical Trial Registration: ClinicalTrials.gov study ID NCT<\/jats:styled-content>00493389)<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22358","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T09:16:45Z","timestamp":1510910205000},"source":"Crossref","is-referenced-by-count":2,"title":["Circulating PCSK<\/scp>9 is lowered acutely following surgery"],"prefix":"10.1002","volume":"32","author":[{"given":"Irena","family":"Druce","sequence":"first","affiliation":[{"name":"Clinical Research Laboratory Division of Endocrinology and Metabolism Department of Medicine University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Abujrad","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory Division of Endocrinology and Metabolism Department of Medicine University of Ottawa Ottawa ON Canada"},{"name":"Chronic Disease Program Ottawa Hospital Research Institute The Ottawa Hospital Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seham","family":"Chaker","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory Division of Endocrinology and Metabolism Department of Medicine University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Meggison","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Ottawa Hospital University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Hill","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery The Ottawa Hospital University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Raymond","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory Division of Endocrinology and Metabolism Department of Medicine University 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