{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:20:55Z","timestamp":1762507255205,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T00:00:00Z","timestamp":1512172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Background<\/jats:title>The current investigation was aimed to explore the potential associations of SNP<\/jats:styled-content>s within ADRB<\/jats:styled-content>2<\/jats:italic>, ADRB<\/jats:styled-content>1, NPY<\/jats:styled-content>,<\/jats:italic> and ADRA<\/jats:styled-content>1A<\/jats:italic> with risk and prognosis of cervical vertigo.<\/jats:p><\/jats:sec>Methods<\/jats:title>Altogether 216 patients with cervical vertigo and 204 healthy controls were gathered, and their DNA<\/jats:styled-content>s were extracted utilizing the whole\u2010blood DNA<\/jats:styled-content> extraction kit. Besides, the PCR<\/jats:styled-content> reactions were conducted using the TaqManR<\/jats:sup> single nucleotide polymorphism (SNP<\/jats:styled-content>) genotyping assays, and the SNP<\/jats:styled-content>s were detected on the 7900HT<\/jats:styled-content> real\u2010time fluorogenic quantitative polymerase chain reaction (PCR<\/jats:styled-content>) instrument. Finally, the severity of cervical vertigo was classified according to the JOA<\/jats:styled-content> scoring, and the recovery rate (RR<\/jats:styled-content>) of cervical vertigo was calculated in light of the formula as: urn:x-wiley:08878013:media:jcla22366:jcla22366-math-0001<\/jats:alt-text><\/jats:graphic><\/jats:disp-formula><\/jats:p><\/jats:sec>Results<\/jats:title>The SNP<\/jats:styled-content>s within ADRA<\/jats:styled-content>1A<\/jats:italic> [rs1048101 (T>C) and rs3802241 (C>T)], NPY<\/jats:styled-content><\/jats:italic> [rs16476 (A>C), rs16148 (T>C), and rs5574 (C>T)], ADRB<\/jats:styled-content>1<\/jats:italic> [rs28365031 (A>G)] and ADRB<\/jats:styled-content>2<\/jats:italic> [rs2053044 (A>G)] were all significantly associated with regulated risk of cervical vertigo (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05). Haplotypes of ADRA<\/jats:styled-content>1A<\/jats:italic> [CT<\/jats:styled-content> and TC<\/jats:styled-content>] and NPY<\/jats:styled-content><\/jats:italic> [CCT<\/jats:styled-content> and ATT<\/jats:styled-content>] were also suggested as the susceptible factors of cervical vertigo in comparison with other haplotypes. Furthermore, the SNP<\/jats:styled-content>s within ADRA<\/jats:styled-content>1A<\/jats:italic> [rs1048101 (T>C)], NPY<\/jats:styled-content><\/jats:italic> [rs16476 (A>C), rs16148 (T>C)], as well as ADRB<\/jats:styled-content>1<\/jats:italic> [rs28365031 (A>G)] all appeared to predict the prognosis of cervical vertigo in a relatively accurate way (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05). Ultimately, the haplotypes of ADRA<\/jats:styled-content>1A<\/jats:italic> (CC<\/jats:styled-content>) and NPY<\/jats:styled-content><\/jats:italic> (CCT<\/jats:styled-content>) tended to decrease the RR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The SNP<\/jats:styled-content>s within ADRB<\/jats:styled-content>2<\/jats:italic>, ADRB<\/jats:styled-content>1, NPY<\/jats:styled-content>,<\/jats:italic> and ADRA<\/jats:styled-content>1A<\/jats:italic> might act as the diagnostic biomarkers and treatment targets for cervical vertigo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22366","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T07:26:41Z","timestamp":1512199601000},"source":"Crossref","is-referenced-by-count":5,"title":["The correlation between SNP<\/scp>s within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo"],"prefix":"10.1002","volume":"32","author":[{"given":"Jianlong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Orthopedics the Second Hospital of Shandong University Jinan City Shandong Province China"},{"name":"Department of Orthopedics the Fourth Hospital of Jinan Jinan City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinliang","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics the Fourth Hospital of Jinan Jinan City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengsong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics the Fourth Hospital of Jinan Jinan City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1787-9141","authenticated-orcid":false,"given":"Chunzheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics the Second Hospital of Shandong University Jinan City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/jmt.2006.14.3.56E"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1752-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3583-z"},{"key":"e_1_2_5_5_1","first-page":"E583","article-title":"Pathogenesis, diagnosis, and treatment of cervical vertigo","volume":"18","author":"Li Y","year":"2015","journal-title":"Pain 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