{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:21:23Z","timestamp":1762867283364,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271914"],"award-info":[{"award-number":["81271914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY12H16025"],"award-info":[{"award-number":["LY12H16025"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Introduction<\/jats:title>Cancer antigen 125 (CA<\/jats:styled-content>125) and human epididymis protein 4 (HE<\/jats:styled-content>4) are biomarkers for ovarian cancer. Their specificity and sensitivity are often limited during pregnancy as a result of great fluctuations. The risk of ovarian malignancy algorithm (ROMA<\/jats:styled-content>) score, which combines CA<\/jats:styled-content>125, HE<\/jats:styled-content>4, and menopausal status, may improve diagnostic performance. There are no reports regarding the ROMA<\/jats:styled-content> index in pregnant women. Therefore, the aim of our study was to establish appropriate reference intervals (RI<\/jats:styled-content>s) for the ROMA<\/jats:styled-content> index in pregnant Chinese women and compare them with those of CA<\/jats:styled-content>125 and HE<\/jats:styled-content>4 during pregnancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum concentrations of CA<\/jats:styled-content>125 and HE<\/jats:styled-content>4 were simultaneously measured in healthy pregnant women via electrochemiluminescence immunoassay (ECLIA<\/jats:styled-content>). The ROMA<\/jats:styled-content> index was calculated using premenopausal algorithms.<\/jats:p><\/jats:sec>Results<\/jats:title>The RI<\/jats:styled-content>s for the ROMA<\/jats:styled-content> index calculated by premenopausal algorithms were substantially closer to the normal range in the first 2 trimesters. For pregnant women, the great misclassifications identified in CA<\/jats:styled-content>125 may be reversed by the use of ROMA<\/jats:styled-content> index.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We established the RI<\/jats:styled-content>s for HE<\/jats:styled-content>4 and CA<\/jats:styled-content>125, as well as the ROMA<\/jats:styled-content> index, in pregnant women at different gestational periods. The ROMA<\/jats:styled-content> index is suggested to be a more promising tumor marker for pregnant women diagnosed with malignance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22368","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T12:18:50Z","timestamp":1512044330000},"source":"Crossref","is-referenced-by-count":8,"title":["Measurement of HE<\/scp>4 and CA<\/scp>125 and establishment of reference intervals for the ROMA<\/scp> index in the sera of pregnant women"],"prefix":"10.1002","volume":"32","author":[{"given":"Jie","family":"Lu","sequence":"first","affiliation":[{"name":"Clinical Laboratory Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 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