{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:35Z","timestamp":1753869395852,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Background<\/jats:title>In this study, we aimed to identify a simple method for evaluating respiratory function using complete blood count parameters.<\/jats:p><\/jats:sec>Methods<\/jats:title>The complete blood count parameters, including red blood cell (RBC) count, hemoglobin (Hb) level, lymphocyte (Lym) and platelet (Plt) count, and partial pressure of oxygen (PO2<\/jats:sub>) level, were measured using automated analyzers in patients with chronic obstructive pulmonary disease (COPD), aged subjects, and young subjects (control group). The red cell index (RCI) was calculated using the following equation: (RBC\u00a0\u00d7\u00a0Hb)\/(Lym\u00a0\u00d7\u00a0Plt); in theory, the RCI is inversely proportional to the respiratory function.<\/jats:p><\/jats:sec>Results<\/jats:title>We observed a significant relationship between the RCI and PCO2<\/jats:sub> values, and between the RCI and FEV1\/FVC values (P<\/jats:italic>\u00a0<\u00a0.05). The RCI in the COPD, and aged subject groups were all significantly higher than that in the control group (P<\/jats:italic>\u00a0<\u00a0.05). The cutoff value for normal respiratory function was 2.3. The positive rates for an abnormal increase in RCI were also considerably higher in each observation group than in the control group (P<\/jats:italic>\u00a0<\u00a0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The RCI can be considered as a simple and effective tool for evaluating respiratory function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22385","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T07:02:43Z","timestamp":1515999763000},"source":"Crossref","is-referenced-by-count":9,"title":["Surrogate scale for evaluating respiratory function based on complete blood count parameters"],"prefix":"10.1002","volume":"32","author":[{"given":"Yang","family":"Guang","sequence":"first","affiliation":[{"name":"College of Medical Laboratory Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Jie","sequence":"additional","affiliation":[{"name":"College of Medical Laboratory Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Medical Laboratory Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-1168","authenticated-orcid":false,"given":"Liu","family":"Hui","sequence":"additional","affiliation":[{"name":"College of Medical Laboratory Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15071"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2016.05.015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-201184"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.01.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2004.13.9.12963"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.163"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08958370490499906"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500400024768"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6232397"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2011.606505"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352090"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0954-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.210.285"},{"key":"e_1_2_6_15_1","first-page":"69","article-title":"Temperature correction of blood gas values","volume":"1","author":"Shapiro BA","year":"1995","journal-title":"Respir Care Clin N Am"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-5153.2008.00275.x"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:23:48Z","timestamp":1695515028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/jcla.22385"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22385","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"type":"print","value":"0887-8013"},{"type":"electronic","value":"1098-2825"}],"subject":[],"published":{"date-parts":[[2018,1,15]]},"article-number":"e22385"}}