{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:19:10Z","timestamp":1782796750916,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific and Technological Project of Henan Province","award":["172102310077"],"award-info":[{"award-number":["172102310077"]}]},{"name":"National Science Technology Pillar Program in the 12nd Five-year Plan","award":["2014BAI07B00"],"award-info":[{"award-number":["2014BAI07B00"]}]},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special","doi-asserted-by":"crossref","award":["2014-1-4011"],"award-info":[{"award-number":["2014-1-4011"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Background<\/jats:title>The incidence of dilated cardiomyopathy (DCM<\/jats:styled-content>) has increased in recent years, and many studies have sought to further improve the general understanding of this condition. Previous studies have demonstrated that some single nucleotide polymorphisms (SNP<\/jats:styled-content>s) associated with systemic lupus erythematosus also affect susceptibility to DCM<\/jats:styled-content>, suggesting that immune\u2010related diseases may share similar genetic susceptibility. Recent large\u2010scale and genome\u2010wide association studies have identified NCR<\/jats:styled-content>3<\/jats:italic>, NOTCH<\/jats:styled-content>4<\/jats:italic>, CYP<\/jats:styled-content>1A2<\/jats:italic>, ITGA<\/jats:styled-content>1<\/jats:italic>, OPRM<\/jats:styled-content>1<\/jats:italic>, ST<\/jats:styled-content>8SIA<\/jats:styled-content>2<\/jats:italic>, and LINC<\/jats:styled-content>00704<\/jats:italic> as genetic risk factors associated with cardiac manifestations of neonatal lupus. Here, we aimed to determine whether these SNP<\/jats:styled-content>s conferred susceptibility to DCM<\/jats:styled-content> in the Chinese Han population.<\/jats:p><\/jats:sec>Methods<\/jats:title>We investigated the relationship between these polymorphisms and DCM<\/jats:styled-content> risk in 273 patients with DCM<\/jats:styled-content> and 548 healthy controls. Genotyping was performed using MassArray iPLEX<\/jats:styled-content> system.<\/jats:p><\/jats:sec>Results<\/jats:title>Logistic regression analysis indicated that the T allele of rs3134942 in NOTCH<\/jats:styled-content>4<\/jats:italic> gene increased the risk of DCM<\/jats:styled-content> by 61% compared with the G allele (P<\/jats:italic>a<\/jats:italic><\/jats:sub>\u00a0=\u00a06.57\u00a0\u00d7\u00a010\u22123<\/jats:sup>). The SNP<\/jats:styled-content> rs3134942 was also significantly associated with increased DCM<\/jats:styled-content> risk in the additive (P<\/jats:italic>a<\/jats:italic><\/jats:sub>\u00a0=\u00a06.57\u00a0\u00d7\u00a010\u22123<\/jats:sup>) and dominant models (P<\/jats:italic>a<\/jats:italic><\/jats:sub>\u00a0=\u00a01.01\u00a0\u00d7\u00a010\u22122<\/jats:sup>). Additionally, rs2472299 in CYP<\/jats:styled-content>1A2<\/jats:italic> gene showed suggestive association with reduced risk of DCM<\/jats:styled-content> in the dominant model (P<\/jats:italic>a<\/jats:italic><\/jats:sub>\u00a0=\u00a04.24\u00a0\u00d7\u00a010\u22122<\/jats:sup>) and was correlated with smoking status in patients with DCM<\/jats:styled-content> (P<\/jats:italic>a<\/jats:italic><\/jats:sub>\u00a0=\u00a01.56\u00a0\u00d7\u00a010\u22122<\/jats:sup>).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings suggested that rs3134942 in NOTCH<\/jats:styled-content>4<\/jats:italic> may be involved in DCM<\/jats:styled-content> risk. Further, studies in larger and ethnically diverse populations are required to confirm the results reported in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22436","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T08:21:49Z","timestamp":1522052509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NOTCH<\/scp>4<\/i> is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case\u2010control study"],"prefix":"10.1002","volume":"32","author":[{"given":"Xiaoqing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Key Laboratory of Laboratory Medicine of Henan Province The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of 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