{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:09:50Z","timestamp":1778134190783,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Plan Project of Taizhou City","award":["1701KY07"],"award-info":[{"award-number":["1701KY07"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) is a disease associated with a higher incidence and mortality, and some host genetic polymorphisms have been reported as potential factors contributing to the development of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>. In view of this, the study was conducted to investigate the effects of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic> gene polymorphisms and perioperative blood transfusion on prognosis of patients with gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 142 patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> (case group) and 150 healthy controls (control group) were enrolled. Relationship between <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic> gene polymorphisms, perioperative blood transfusion, and clinical pathological parameters of patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> after operation was analyzed. Kaplan\u2010Meier curve was applied for analyzing survival rate of patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, and Cox multivariate regression analysis for prognostic factors of patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic>*03 gene was increased in patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> with <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic>*03 genotype had higher number of tumor size &gt;6\u00a0cm, deeper depth of infiltration, higher <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> rate, and later stage of disease. Patients with <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic>*03 genotype had lower survival rate compared with other genotypes. Anemia before operation, depth of infiltration in T3 stage and T4 stage, <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> in N1 stage and N2 stage, and <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic>*03 genotype were regarded as independent risk factors for patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrate that <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1<\/jats:italic>*03 genotype and perioperative blood transfusion are not conducive to the prognosis of patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, which could provide a reference for the treatment of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22443","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T12:38:54Z","timestamp":1524055134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i><scp>HLA<\/scp>\u2010<scp>DQB<\/scp>1*03<\/i> genotype and perioperative blood transfusion are not conducive to the prognosis of patients with gastric cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"Shen\u2010Kang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Taizhou Hospital of Zhejiang Province  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei\u2010Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Taizhou Hospital of Zhejiang Province  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Taizhou Hospital of Zhejiang Province  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Taizhou Hospital of Zhejiang Province  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-9386","authenticated-orcid":false,"given":"Yong\u2010Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Surgery Taizhou Hospital of Zhejiang Province  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.01.029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350884"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0706-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32834a7f66"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-1057"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.14.018"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2015.56.5.1177"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2755"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3271"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.09.043"},{"key":"e_1_2_6_13_1","first-page":"1874","article-title":"Genotyping HLA\u2010DRB1 and HLA\u2010DQB1 alleles in Japanese patients with normal tension glaucoma","volume":"16","author":"Suzuki M","year":"2010","journal-title":"Mol Vis"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.12.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.06.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-004-0723-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.08.029"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2010.10.4.196"},{"key":"e_1_2_6_19_1","first-page":"2179","article-title":"New guidelines to evaluate the response to treatment \u201cRECIST\u201d","volume":"27","author":"Sasaki T","year":"2000","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000237"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0550-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S103901"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i23.3628"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.03.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.590112.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91496-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.04112.x"},{"key":"e_1_2_6_28_1","first-page":"404","article-title":"Association of HLA\u2010DQB1*0301 and HLA","volume":"93","author":"Wu MSCYT","year":"2002","journal-title":"Cancer Sci"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i48.7762"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.06.004"},{"issue":"1","key":"e_1_2_6_31_1","first-page":"CD007148","article-title":"Pre and peri\u2010operative erythropoietin for reducing allogeneic blood transfusions in colorectal cancer surgery","author":"Devon KM","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004322"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.004016"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.112813"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.17.8009"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000096"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.3.1427"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.07.007"},{"key":"e_1_2_6_39_1","first-page":"837","article-title":"[Effect of perioperative blood transfusion on the prognosis of gastric cancer]","volume":"37","author":"Cui J","year":"2015","journal-title":"Zhonghua Zhong Liu Za Zhi"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T18:10:33Z","timestamp":1694974233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jcla.22443"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22443","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,18]]},"assertion":[{"value":"2017-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22443"}}