{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:06:34Z","timestamp":1768683994591,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transferrin is the major plasma transport protein for iron. We aimed to investigate the characteristics of transferrin variant by carbohydrate\u2010deficient transferrin (<jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content>) test using capillary zone electrophoresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> tests of 2449 patients from March 2009 to May 2017 at a tertiary hospital in Korea. <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> was quantified using a Capillarys 2 system (Sebia, Lisses, France) by capillary zone electrophoresis. The characteristics of variant transferrin patterns using electropherogram of <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> tests were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010seven (3.1%) patients were classified as variant transferrin. Mean age of these patients was 51.8\u00a0years, and the male\u2010to\u2010female ratio was 3.5:1. The most common variants were the <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> variants (n\u00a0=\u00a037), followed by the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> variants (n\u00a0=\u00a027), unclear patterns (n\u00a0=\u00a07), <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> variants (n\u00a0=\u00a03), <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> variants (n\u00a0=\u00a02), misclassification (n\u00a0=\u00a01). In the variant Tf group, the most common disease was alcoholic liver cirrhosis (n\u00a0=\u00a022, 28.6%), followed by the toxic effects of substances (n\u00a0=\u00a017, 22.1%), and mental and behavioral disorders attributable to alcohol (n\u00a0=\u00a011, 14.3%). Nonvariant group showed a predominance of the toxic substance effects (n\u00a0=\u00a0880, 37.1%), a personal history of suicide attempts (n\u00a0=\u00a0634, 26.7%), and mental and behavioral disorders due to alcohol (n\u00a0=\u00a0336, 14.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We analyzed the basic characteristics of variant transferrin by <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> tests using capillary zone electrophoresis. The prevalence of variant transferrin was 3.1% of the study subjects. Male patients, alcohol abusers, and liver cirrhosis patients predominated in the variant transferrin population. Further prospective studies are warranted to elucidate variant transferrin in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22451","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T17:29:26Z","timestamp":1523986166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The characteristics of transferrin variants by carbohydrate\u2010deficient transferrin tests using capillary zone electrophoresis"],"prefix":"10.1002","volume":"32","author":[{"given":"Gilsung","family":"Yoo","sequence":"first","affiliation":[{"name":"Departments of Laboratory Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kap Joon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-8443","authenticated-orcid":false,"given":"Jong\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201400243"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1987.tb01922.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2012.660537"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.10.011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn017"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02124.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.07.015"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.03.018"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.03.033"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700211"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2003-5601"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.7.1447"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0974-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.03.005"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T18:11:26Z","timestamp":1694974286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jcla.22451"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22451","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22451"}}