{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:17:27Z","timestamp":1790662647705,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"\n Background<\/jats:title>\n \n Syntax score (\n SS<\/jats:styled-content>\n ), which is an angiographic tool used in grading the complexity of coronary artery disease (\n CAD<\/jats:styled-content>\n ), has prognostic importance in coronary artery disease (\n CAD<\/jats:styled-content>\n ) and provides important information regarding selection of revascularization strategy. C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ) and albumin are indicators of inflammation, and high levels of them are associated with high\n SS<\/jats:styled-content>\n . We aimed to investigate whether baseline\n CRP<\/jats:styled-content>\n to albumin ratio C\u2010Reactive Protein\/Albumin Ratio (\n CAR<\/jats:styled-content>\n ), an easily available and novel inflammatory marker, is associated with\n SS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n A total 403 consecutive patients with stabile angina pectoris, who underwent coronary angiography for suspected\n CAD<\/jats:styled-content>\n from January 2015 to June 2016, were classified into two groups, low\n SS<\/jats:styled-content>\n (\u226422) and intermediate\u2010high\n SS<\/jats:styled-content>\n (>22).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n C\u2010Reactive Protein\/Albumin Ratio was significantly higher in patients with intermediate\u2010high\n SS<\/jats:styled-content>\n group (\n P<\/jats:italic>\n \u00a0<\u00a0.001). In multivariate regression analysis,\n CAR<\/jats:styled-content>\n remained an independent predictor of intermediate\u2010high\n SS<\/jats:styled-content>\n group together with hypertension and\n LDL<\/jats:styled-content>\n . The predictive performance of\n CAR<\/jats:styled-content>\n ,\n CRP<\/jats:styled-content>\n , and albumin was compared by\n ROC<\/jats:styled-content>\n curve analysis.\n CAR<\/jats:styled-content>\n surpassed\n CRP<\/jats:styled-content>\n and albumin in predicting intermediate\u2010high\n SS<\/jats:styled-content>\n group.\n CAR<\/jats:styled-content>\n >6.3 predicted an intermediate\u2010high\n SS<\/jats:styled-content>\n with sensitivity and specificity of 86.8% and 43.4%, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n C\u2010Reactive Protein\/Albumin Ratio was more tightly associated with the complexity and severity of\n CAD<\/jats:styled-content>\n than\n CRP<\/jats:styled-content>\n and albumin alone and was found to be an independent predictor for intermediate\u2010high\n SS<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.22457","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T08:31:53Z","timestamp":1524040313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Relationship between C\u2010reactive protein\/albumin ratio and coronary artery disease severity in patients with stable angina pectoris"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-315X","authenticated-orcid":false,"given":"Yavuz","family":"Karaba\u011f","sequence":"first","affiliation":[{"name":"Department of Cardiology Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"\u00c7a\u011fda\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Rencuzogullari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"Karakoyun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130nan\u00e7","family":"Arta\u00e7","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u011fan","family":"\u0130li\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eray","family":"Atalay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kafkas University Medical Faculty Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Yesin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kars Harakani State Hospital Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Ozan","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u0130zmir Katip \u00c7elebi University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Halil Tanbo\u011fa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ataturk University Medical Faculty Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"DonBR KaysenG eds.Poor nutritional status and inflammation: serum albumin: relationship to inflammation and nutrition. 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