{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:32:26Z","timestamp":1759743146966,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Xeroderma pigmentosum group G (<jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content>) plays an important role in maintaining the stability and integrity of genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. Previous studies demonstrate some <jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content> gene polymorphisms are associated with susceptibility to gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The association between <jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content> rs2094258 polymorphism and <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> risk was investigated first by a hospital\u2010based case\u2010control study involving 386 patients and 439 controls and then by a meta\u2010analysis. The polymorphism was genotyped by polymerase chain reaction\u2010restriction fragment length polymorphism (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Xeroderma pigmentosum group G rs2094258 polymorphism was associated with an increased risk of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> in a Chinese population. The meta\u2010analysis did not reveal any significant difference in the overall population. Subgroup analysis of geographic locations showed a significant association between the <jats:styled-content style=\"fixed-case\">XPG<\/jats:styled-content> gene rs2094258 polymorphism and <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> risk in Southern China. Stratification analysis further indicated significant associations in hospital\u2010based studies and studies using <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> in Southern China. Nevertheless, the findings of this meta\u2010analysis should be validated by well\u2010designed large\u2010scale case\u2010control studies among other ethnicities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22564","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T08:38:50Z","timestamp":1525682330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between the <scp>XPG<\/scp> gene rs2094258 polymorphism and risk of gastric cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"Zhe","family":"Zhang","sequence":"first","affiliation":[{"name":"General Surgery Department Tongde Hospital of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiefeng","family":"Yin","sequence":"additional","affiliation":[{"name":"General Surgery Department Tongde Hospital of Zhejiang Province  Hangzhou 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