{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:15:09Z","timestamp":1787879709711,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pregnancy is accompanied by profound changes in lipid metabolism. We aimed to assess whether effects of second trimester body mass index and maternal lipid concentrations are associated with an increased risk of adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the serum levels of maternal lipids during the second trimester in pregnancy, and analyzed associations between the lipid levels and the risk of adverse pregnancy outcome. Seven hundred and seventy\u2010four pregnant women were enrolled in this study between February 2016 and June 2016. Multivariate logistic regression analysis was conducted to estimate the relative risk between maternal lipids and adverse pregnancy outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the control group, during the second trimester of pregnancy,\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      , and Lp(a) were risk factors for gestational diabetes mellitus; middle trimester pregnancy\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      , Lp(a), and\n                      <jats:styled-content style=\"fixed-case\">APO<\/jats:styled-content>\n                      \u2010B were risk factors for pre\u2010eclampsia; second trimester\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                      \u2010C were risk factors for macrosomia; age and Lp(a) were uterine atony postpartum hemorrhage risk factors, while\n                      <jats:styled-content style=\"fixed-case\">APO<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>\n                      was a protective factor of uterine inertia and postpartum hemorrhage; second trimester\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">TCH<\/jats:styled-content>\n                      , Lp(a), and\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                      \u2010C were risk factors for fetal distress, while parity was a protective factor against fetal distress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Abnormal blood lipid levels in pregnancy are significantly associated with\n                      <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>\n                      , pre\u2010eclampsia, and other adverse pregnancy outcomes.\n                    <\/jats:p>\n                  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