{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:51:13Z","timestamp":1784357473723,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Background<\/jats:title>Combination of dyslipidemic phenotypes, including elevated plasma levels of low\u2010density lipoprotein cholesterol (LDL<\/jats:styled-content>\u2010C), elevated plasma triglycerides (TG<\/jats:styled-content>), and decreased low\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C) concentrations, is important because of the association of individual phenotypes with increased risk of cardiovascular disease (CVD<\/jats:styled-content>). We investigated the prevalence of combined dyslipidemias and their effects on CVD<\/jats:styled-content> risk in an Iranian large population.<\/jats:p><\/jats:sec>Method<\/jats:title>A total of 9847 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD<\/jats:styled-content>) cohort study. Anthropometric parameters and biochemical indices were measured in all of the subjects. Different types of combined dyslipidemias including high TG<\/jats:styled-content>\u00a0+\u00a0low HDL<\/jats:styled-content>\u2010C, high TG<\/jats:styled-content>\u00a0+\u00a0low HDL<\/jats:styled-content>\u2010C\u00a0+\u00a0high LDL<\/jats:styled-content>\u2010C, low HDL<\/jats:styled-content>\u2010C\u00a0+\u00a0high LDL<\/jats:styled-content>\u2010C, high TG<\/jats:styled-content>\u00a0+\u00a0high LDL<\/jats:styled-content>\u2010C, and finally high TG<\/jats:styled-content>\u00a0+\u00a0high LDL<\/jats:styled-content>\u2010C\u00a0+\u00a0low HDL<\/jats:styled-content>\u2010C were considered. Ten\u2010year CVD<\/jats:styled-content> risk was calculated using the QRISK<\/jats:styled-content>2 risk algorithm and adjustments were made as suggested by the Joint British Societies\u2019 (JBS<\/jats:styled-content>2). Logistic regression analyses were performed to determine the association between different combined dyslipidemias and categorical QRISK<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 3952 males and 5895 females were included in this current study. Among the included subjects, 83.4% had one form of dyslipidemia, and 16.6% subjects were not dyslipidemic. The mean age was 48.88\u00a0\u00b1\u00a07.9 and 47.02\u00a0\u00b1\u00a08.54\u00a0years for dyslipidemic and nondyslipidemic groups, respectively. The results showed that the frequency of dyslipidemia was 98%, 87.1%, and 90% in subjects with metabolic syndrome, CVD<\/jats:styled-content>, and diabetes, respectively. Our results suggested that around 15.7% of study population were at 10\u00a0years CVD<\/jats:styled-content> risk (high \u226520) and it was higher in men than women (P<\/jats:italic>\u00a0<\u00a0.001). Moreover, risk of CVD<\/jats:styled-content> was higher in TG<\/jats:styled-content>\u2191 & HDL<\/jats:styled-content>\u2193 & LDL<\/jats:styled-content>\u2191 group than other groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Prevalence of dyslipidemia was 83.4% among Iranian adults. The results showed that individuals with increased plasma TG<\/jats:styled-content> and LDL<\/jats:styled-content>\u2010C, and low HDL<\/jats:styled-content>\u2010C levels had the highest 10\u00a0years CVD<\/jats:styled-content> risk compared to other combined dyslipidemic phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22579","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T10:00:26Z","timestamp":1529575226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence of combined and noncombined dyslipidemia in an Iranian population"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-729X","authenticated-orcid":false,"given":"Susan","family":"Darroudi","sequence":"first","affiliation":[{"name":"Student Research Committee Department of Modern Sciences and Technologies Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Saberi\u2010Karimian","sequence":"additional","affiliation":[{"name":"Student Research Committee Department of Modern Sciences and Technologies Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tayefi","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Faculty of Medicine Mashhad University of Medical Science Mashhad Iran"},{"name":"Metabolic Syndrome Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheil","family":"Arekhi","sequence":"additional","affiliation":[{"name":"Student Research Committee Faculty of Medicine Mashhad University of Medical Science Mashhad Iran"},{"name":"Evidence Based Medicine Research group Faculty of Medicine Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Motamedzadeh Torghabeh","sequence":"additional","affiliation":[{"name":"Student Research Committee Faculty of Medicine Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad Reza","family":"Seyedzadeh Sani","sequence":"additional","affiliation":[{"name":"Student Research Committee Faculty of Medicine Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Moohebati","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Heidari\u2010Bakavoli","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Reza","family":"Azarpajouh","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Safarian","sequence":"additional","affiliation":[{"name":"Biochemistry of Nutrition Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"A. Ferns","sequence":"additional","affiliation":[{"name":"Department of Biostatistics & Epidemiology School of Health Management & Social Determinants of Health Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibollah","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Biostatistics & Epidemiology School of Health Management & Social Determinants of Health Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Parizadeh","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Biochemistry of Nutrition Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naghme","family":"Mokhber","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeleh","family":"Mahdizadeh","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Asghar","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Head of the Health Center N.2 of Mashhad Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amir Hossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Neurogenic Inflammation Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Biotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences Mashhad Iran"},{"name":"School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ghayour\u2010Mobarhan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Institutes of Health National Heart Lung Blood Institute.Atp iii guidelines at\u2010a\u2010glance quick desk reference. 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